ArticleMolecular and cellular biology2003
Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
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- Transcriptional activity of erythroid Kruppel-like factor (EKLF/KLF1) modulated by PIAS3 (protein inhibitor of activated STAT3).The Journal of biological chemistry · 2015Article
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- Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct.Molecular and cellular biology · 2012Article
- Gene repressive activity of RIP140 through direct interaction with CDK8.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Phosphorylation of CtBP1 by cAMP-dependent protein kinase modulates induction of CYP17 by stimulating partnering of CtBP1 and 2.The Journal of biological chemistry · 2008Article
- RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27.Acta physiologica (Oxford, England) · 2008Review
- Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells.Molecular cancer · 2007Article
- Evidence that mono-ADP-ribosylation of CtBP1/BARS regulates lipid storage.Molecular biology of the cell · 2007Article
- Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha.Molecular endocrinology (Baltimore, Md.) · 2007Article
- Molecular basis for repression of liver X receptor-mediated gene transcription by receptor-interacting protein 140.The Biochemical journal · 2007Article
- Heterozygous missense mutations in steroidogenic factor 1 (SF1/Ad4BP, NR5A1) are associated with 46,XY disorders of sex development with normal adrenal function.The Journal of clinical endocrinology and metabolism · 2007Article
- Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation.The EMBO journal · 2006Article
- The nuclear receptor transcriptional coregulator RIP140.Nuclear receptor signaling · 2006Article
- Nuclear compartmentalization of N-CoR and its interactions with steroid receptors.Molecular and cellular biology · 2006Article
- Receptor-interacting protein 140 is a repressor of the androgen receptor activity.Molecular endocrinology (Baltimore, Md.) · 2006Article
- ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases.Nucleic acids research · 2006Article
- Functional interactions with Pit-1 reorganize co-repressor complexes in the living cell nucleus.Journal of cell science · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulation of gene transcription by nuclear receptors involves association with numerous coregulators. Receptor-interacting protein 140 (RIP140) is a corepressor that negatively regulates the ligand-induced activity of several nuclear receptors, including the glucocorticoid receptor (GR). In the present study, we have characterized the role of the intranuclear localization of RIP140 in its corepressor activity. In the absence of ligand-activated GR, RIP140 is localized in small nuclear foci targeted by a 40-amino-acid-long sequence. Although the focus-targeting domain overlaps with a binding sequence for the corepressor CtBP (C-terminal binding protein), interaction with CtBP is not involved in the localization. RIP140 foci do not correspond to PML bodies but partly colocalize with domains harboring the corepressor SMRT. Upon ligand binding, GR and RIP140 are redistributed to large nuclear domains distinct from the RIP140 foci. The redistribution requires regions of RIP140 with corepressor activity, as well as the DNA-binding domain of GR. Furthermore, we show that full RIP140 corepressor activity is contributed both by C-terminal receptor-binding LXXLL motifs and interaction with the CtBP corepressor. In conclusion, our results suggest that the corepressor function of RIP140 is multifaceted and involves binding to nuclear receptors, as well as additional functions mediated by the formation and intranuclear relocalization of a repressive protein complex.
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