ArticleMolecular and cellular biology2003
The Sp1 family of transcription factors is involved in p27(Kip1)-mediated activation of myelin basic protein gene expression.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Meta-Analysis of Differential Connectivity in Gene Co-Expression Networks in Multiple Sclerosis.International journal of molecular sciences · 2016Pooled it
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- Demyelination and impaired oligodendrogenesis in the corpus callosum following lead exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs.Cell discovery · 2024Article
- The emerging role of galectins in (re)myelination and its potential for developing new approaches to treat multiple sclerosis.Cellular and molecular life sciences : CMLS · 2020Review
- Leukemia/lymphoma-related factor (LRF) exhibits stage- and context-dependent transcriptional controls in the oligodendrocyte lineage and modulates remyelination.Journal of neuroscience research · 2017Article
- Everolimus (RAD001) inhibits the proliferation of rat vascular smooth muscle cells by up-regulating the activity of the p27/kip1 gene promoter.Anatolian journal of cardiology · 2016Article
- The role of galectin-4 in physiology and diseases.Protein & cell · 2016Review
- A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD).Human molecular genetics · 2015Article
- Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer.Nature neuroscience · 2014Article
- Jab1 regulates Schwann cell proliferation and axonal sorting through p27.The Journal of experimental medicine · 2014Article
- De-repression of myelin-regulating gene expression after status epilepticus in mice lacking the C/EBP homologous protein CHOP.International journal of physiology, pathophysiology and pharmacology · 2014Article
- Vsx2 controls eye organogenesis and retinal progenitor identity via homeodomain and non-homeodomain residues required for high affinity DNA binding.PLoS genetics · 2012Article
- Specification and maintenance of oligodendrocyte precursor cells from neural progenitor cells: involvement of microRNA-7a.Molecular biology of the cell · 2012Article
- Towards resolving the transcription factor network controlling myelin gene expression.Nucleic acids research · 2011Article
- Article
- Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation.PloS one · 2010Article
- An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis.Oncogene · 2010Article
- Multiple signaling pathways converge to regulate bone-morphogenetic-protein-dependent glial gene expression.Developmental neuroscience · 2009Article
- Essential function, sophisticated regulation and pathological impact of the selective RNA-binding protein QKI in CNS myelin development.Future neurology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
p27(Kip1) levels increase in many cells as they leave the cell cycle and begin to differentiate. The increase in p27(Kip1) levels generally precedes the expression of differentiation-specific genes. Previous studies from our laboratory showed that the overexpression of p27(Kip1) enhances myelin basic protein (MBP) promoter activity. This activation is specific to p27(Kip1). Additionally, inhibition of cyclin-dependent kinase activity alone is not sufficient to increase MBP expression. In this study, we focused on understanding how p27(Kip1) can activate gene transcription by using the MBP gene in oligodendrocytes as a model. We show that the enhancement of MBP promoter activity by p27(Kip1) is mediated by a proximal region of the MBP promoter that contains a conserved GC box binding sequence. This sequence binds transcription factors Sp1 and Sp3. Increased expression of p27(Kip1) increases the level of Sp1 promoter binding to the GC box but does not change the level of Sp3 binding. The binding of Sp1 to this element activates the MBP promoter. p27(Kip1) leads to increased Sp1 binding through a decrease in Sp1 protein turnover. Enhancement of MBP promoter activity by an increase in the level of p27(Kip1) involves a novel mechanism that is mediated through the stabilization and binding of transcription factor Sp1.
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