ArticleThe EMBO journal2003
Pti1p and Ref2p found in association with the mRNA 3' end formation complex direct snoRNA maturation.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Genetic and pharmacological evidence for kinetic competition between alternative poly(A) sites in yeast.eLife · 2021Article
- The APT complex is involved in non-coding RNA transcription and is distinct from CPF.Nucleic acids research · 2018Article
- RNA Polymerase II Transcription Attenuation at the Yeast DNA Repair Gene,G3 (Bethesda, Md.) · 2018Article
- Distinct roles of Pcf11 zinc-binding domains in pre-mRNA 3'-end processing.Nucleic acids research · 2017Article
- Transcription termination and the control of the transcriptome: why, where and how to stop.Nature reviews. Molecular cell biology · 2015Review
- Termination of Transcription of Short Noncoding RNAs by RNA Polymerase II.Annual review of biochemistry · 2015Review
- Spp1 at the crossroads of H3K4me3 regulation and meiotic recombination.Epigenetics · 2013Review
- Disengaging polymerase: terminating RNA polymerase II transcription in budding yeast.Biochimica et biophysica acta · 2013Review
- Yeast Swd2 is essential because of antagonism between Set1 histone methyltransferase complex and APT (associated with Pta1) termination factor.The Journal of biological chemistry · 2012Article
- An essential role for Clp1 in assembly of polyadenylation complex CF IA and Pol II transcription termination.Nucleic acids research · 2012Article
- H2B ubiquitylation controls the formation of export-competent mRNP.Molecular cell · 2012Article
- Transcription termination by nuclear RNA polymerases.Genes & development · 2009Article
- The essential N terminus of the Pta1 scaffold protein is required for snoRNA transcription termination and Ssu72 function but is dispensable for pre-mRNA 3'-end processing.Molecular and cellular biology · 2009Article
- The role of the putative 3' end processing endonuclease Ysh1p in mRNA and snoRNA synthesis.RNA (New York, N.Y.) · 2008Article
- Polyadenylation linked to transcription termination directs the processing of snoRNA precursors in yeast.Molecular cell · 2008Article
- Inactivation of cleavage factor I components Rna14p and Rna15p induces sequestration of small nucleolar ribonucleoproteins at discrete sites in the nucleus.Molecular biology of the cell · 2008Article
- Sno/scaRNAbase: a curated database for small nucleolar RNAs and cajal body-specific RNAs.Nucleic acids research · 2007Article
- cis- and trans-Acting determinants of transcription termination by yeast RNA polymerase II.Molecular and cellular biology · 2006Article
- A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation.Molecular cell · 2005Article
- The cotranscriptional assembly of snoRNPs controls the biosynthesis of H/ACA snoRNAs in Saccharomyces cerevisiae.Molecular and cellular biology · 2005Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic RNA polymerase II transcribes precursors of mRNAs and of non-protein-coding RNAs such as snRNAs and snoRNAs. These RNAs have to be processed at their 3' ends to be functional. mRNAs are matured by cleavage and polyadenylation that require a well-characterized protein complex. Small RNAs are also subject to 3' end cleavage but are not polyadenylated. Here we show that two newly identified proteins, Pti1p and Ref2p, although they were found associated with the pre-mRNA 3' end processing complex, are essential for yeast snoRNA 3' end maturation. We also provide evidence that Pti1p probably acts by uncoupling cleavage and polyadenylation, and functions in coordination with the Nrd1p-dependent pathway for 3' end formation of non-polyadenylated transcripts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.