ReviewThe EMBO journal2003
Regulation of neuronal survival and death by extracellular signals during development.
Review in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed.
- The neurotrophin DNT-2 via the Toll-2 receptor regulates neuronal survival and morphology during visual system development.Biology open · 2026Article
- Early life shifts in cortical inhibitory-excitatory balance underlies sensitive periods and skill development.Frontiers in cellular neuroscience · 2026Article
- Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair.Nature communications · 2024Article
- Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis.Nature cell biology · 2023Article
- MicroRNAs in the Mouse Developing Retina.International journal of molecular sciences · 2023Review
- Differentiation signals from glia are fine-tuned to set neuronal numbers during development.eLife · 2022Article
- Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior.Nature communications · 2022Article
- Physiologic maturation is both extrinsically and intrinsically regulated in progenitor-derived neurons.Scientific reports · 2020Article
- CD40L reverse signaling suppresses prevertebral sympathetic axon growth and tissue innervation.Developmental neurobiology · 2019Article
- Sequence specificity despite intrinsic disorder: How a disease-associated Val/Met polymorphism rearranges tertiary interactions in a long disordered protein.PLoS computational biology · 2019Article
- CD40 forward signalling is a physiological regulator of early sensory axon growth.Development (Cambridge, England) · 2019Article
- A cell fitness selection model for neuronal survival during development.Nature communications · 2019Article
- Regional Differences in the Contributions of TNF Reverse and Forward Signaling to the Establishment of Sympathetic Innervation.Developmental neurobiology · 2019Article
- TWE-PRIL reverse signalling suppresses sympathetic axon growth and tissue innervation.Development (Cambridge, England) · 2018Article
- Link N as a therapeutic agent for discogenic pain.JOR spine · 2018Article
- Article
- Homeostatic Regulation of Interneuron Apoptosis During Cortical Development.Journal of experimental neuroscience · 2018Article
- TNF superfamily member APRIL enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo.Experimental neurology · 2017Article
- miRNA-Mediated Regulation of Adult Hippocampal Neurogenesis; Implications for Epilepsy.Brain plasticity (Amsterdam, Netherlands) · 2017Review
- Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Cell death is a prominent feature of the developing vertebrate nervous system, affecting neurons, glial cells and their progenitors. The most extensively studied and best understood phase of cell death occurs in populations of neurons shortly after they begin establishing connections with other neurons and/or non-neural tissues. This phase of cell death makes appropriate adjustments to the relative sizes of interconnected groups of neurons and matches the size of neuronal populations that innervate non-neural tissues to the optimal requirements of these tissues. The fate of neurons during this period of development is regulated by a variety of secreted proteins that either promote survival or bring about cell death after binding to receptors expressed on the neurons. These proteins may be derived from the targets the neurons innervate, the afferents they receive or from associated glial cells, or they may be secreted by the neurons themselves. In this review, I will outline the established and emerging principles that modulate neuronal number in the developing nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.