ArticleBritish journal of cancer2003
In vivo evolution of tumour cells after the generation of double-strand DNA breaks.
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
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- Percutaneous image guided electrochemotherapy of hepatocellular carcinoma: technological advancement.Radiology and oncology · 2020Article
- Effect of electrochemotherapy on human herpesvirus 8 kinetics in classic Kaposi sarcoma.Infectious agents and cancer · 2017Article
- CD4Clinical & experimental metastasis · 2016Article
- The promising alliance of anti-cancer electrochemotherapy with immunotherapy.Cancer metastasis reviews · 2016Review
- Electrochemotherapy induces apoptotic death in melanoma metastases: a histologic and immunohistochemical investigation.Clinical, cosmetic and investigational dermatology · 2016Article
- Structural damage of chicken red blood cells exposed to platinum nanoparticles and cisplatin.Nanoscale research letters · 2014Article
- Dendritic cells recruitment in melanoma metastasis treated by electrochemotherapy.Clinical & experimental metastasis · 2013Article
- Assessment of the tumourigenic and metastatic properties of SK-MEL28 melanoma cells surviving electrochemotherapy with bleomycin.Radiology and oncology · 2012Article
- Tumor destruction using electrochemotherapy followed by CpG oligodeoxynucleotide injection induces distant tumor responses.Cancer immunology, immunotherapy : CII · 2008Article
- Dual therapeutic benefit of electroporation-mediated DNA vaccination in vivo: Enhanced gene transfer and adjuvant activity.OncoimmunologyArticle
- Electrochemotherapy with bleomycin induces hallmarks of immunogenic cell death in murine colon cancer cells.OncoimmunologyArticle
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vitro, the ratio of single- to double-strand DNA breaks (DSB) and their absolute values determine the cell death pathway. The consequences of the generation of various numbers of DSB generated in vivo in tumour cells have been analysed in two different experimental tumour models. Synchronisation of DSB generation and control of their number have been achieved using different doses of bleomycin (BLM) and tumour cell permeabilisation by means of locally delivered electric pulses. According to BLM dose, different cell death pathways are observed. At a low therapeutic dose, a mitotic cell death pathway is detected. It is characterised by the appearance of 'atypical mitosis', TUNEL and caspase-3 positive, 24 h after the treatment, and later by the presence of typical apoptotic figures, mainly TUNEL positive but caspase-3 negative. Caspase-3 is thus an early marker of apoptosis. Mitotic cell death is also followed by lymphocytic infiltration reaction. At high doses of BLM, pseudoapoptosis is detected within a few minutes after the treatment. These cell death pathways are discussed as a function of the number of DSB generated, by comparison with previous results obtained in vitro using BLM or ionising radiation.
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