ArticleBritish journal of cancer2003
The LIM-only protein, LMO4, and the LIM domain-binding protein, LDB1, expression in squamous cell carcinomas of the oral cavity.
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer.Cancer gene therapy · 2024Review
- Circular RNA circBACH2 plays a role in papillary thyroid carcinoma by sponging miR-139-5p and regulating LMO4 expression.Cell death & disease · 2019Article
- LMO4 mediates trastuzumab resistance in HER2 positive breast cancer cells.American journal of cancer research · 2018Article
- Article
- LMO4 is a prognostic marker involved in cell migration and invasion in non-small-cell lung cancer.Journal of thoracic disease · 2016Article
- Article
- The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression.Respiratory research · 2015Article
- Inhibition of TGF-β and EGF pathway gene expression and migration of oral carcinoma cells by mucosa-associated lymphoid tissue 1.British journal of cancer · 2013Article
- LIM-domain-only proteins in cancer.Nature reviews. Cancer · 2013Review
- Concomitant loss of p120-catenin and β-catenin membrane expression and oral carcinoma progression with E-cadherin reduction.PloS one · 2013Article
- Novel amplifications in pediatric medulloblastoma identified by genome-wide copy number profiling.Journal of neuro-oncology · 2012Article
- The LIM adaptor protein LMO4 is an essential regulator of neural crest development.Developmental biology · 2012Article
- Progression of oral squamous cell carcinoma accompanied with reduced E-cadherin expression but not cadherin switch.PloS one · 2012Article
- Liver-specific Ldb1 deletion results in enhanced liver cancer development.Journal of hepatology · 2010Article
- Repression of Lim only protein 4-activated transcription inhibits proliferation and induces apoptosis of normal mammary epithelial cells and breast cancer cells.Clinical & experimental metastasis · 2010Article
- Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear.Developmental biology · 2010Article
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- The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration.Molecular biology of the cell · 2009Article
- Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells.Journal of experimental & clinical cancer research : CR · 2009Article
- LIM only 4 is overexpressed in late stage pancreas cancer.Molecular cancer · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carcinoma cells can lose their epithelial cell characteristics and dedifferentiate into a fibroblast-like cell during progression of a neoplasm. Aberrant expression of oligomeric transcriptional complexes contributes to progression of carcinomas. Although individual transcription factors initiating progression remain unknown, LIM-only protein (LMO) and LIM-domain binding protein (LDB) negatively regulate breast carcinoma cell differentiation. In this study, we investigated the expression of LMO4 and LDB in squamous cell carcinomas of the oral cavity. LMO4 mRNA was amplified in four of six carcinoma tissues and eight of 12 carcinoma cell lines, and LDB1 in three carcinoma tissues and 11 cell lines examined. Immunoprecipitation studies revealed that LMO4 and LDB1 interact with each other in the nuclear milieu of the carcinoma cells indicating the presence of an LMO4-LDB1-mediated transcription complex. Both LMO4 and LDB1 proteins were preferentially localised in the nuclei of carcinoma cells at the invasive front and the immunoreactivity was increased in less-differentiated carcinoma tissues (P<0.01). Carcinoma cells metastasised to the cervical lymph nodes with increased immunoreactivity compared to the primary site of neoplasm (P<0.05). These data suggest that the LMO4-LDB1 complexes may be involved in carcinoma progression possibly through dedifferentiation of squamous carcinoma cells of the oral cavity.
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