ArticleBritish journal of cancer2003
Cancer and the FRA3B/FHIT fragile locus: it's a HIT.
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Fragile histidine triad (FHIT) suppresses gastric cancer via translational regulation of the epigenetic modifier KDM6B.The Journal of biological chemistry · 2026Article
- Review
- The Rosetta Stone Hypothesis-Based Interaction of the Tumor Suppressor Proteins Nit1 and Fhit.Cells · 2023Article
- Protein expression of Fragile Histidine Triad and cyclooxgenase-2 in serrated neoplasia of the colorectum.Oncology letters · 2017Article
- WWOX: a fragile tumor suppressor.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily.The FEBS journal · 2013Article
- Mitochondrial Ca(2+) and apoptosis.Cell calcium · 2012Review
- Investigation of recurrent deletion loci specific to conventional renal cell carcinoma by comparative allelotyping in major epithelial carcinomas.Indian journal of urology : IJU : journal of the Urological Society of India · 2012Article
- Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site.Nature · 2011Article
- Multiple Patterns of FHIT Gene Homozygous Deletion in Egyptian Breast Cancer Patients.International journal of breast cancer · 2011Article
- Common fragile site tumor suppressor genes and corresponding mouse models of cancer.Journal of biomedicine & biotechnology · 2011Review
- Loss of WW domain-containing oxidoreductase expression in the progression and development of gastric carcinoma: clinical and histopathologic correlations.Virchows Archiv : an international journal of pathology · 2010Article
- Fragile histidine triad protein: structure, function, and its association with tumorogenesis.Journal of cancer research and clinical oncology · 2010Review
- Fhit regulates invasion of lung tumor cells.Oncogene · 2010Article
- The effects of Fhit on tumorigenesis after multi-exposure to low-dose radiation.International journal of clinical and experimental medicine · 2009Article
- Nit1 and Fhit tumor suppressor activities are additive.Journal of cellular biochemistry · 2009Article
- Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Fragile gene product, Fhit, in oxidative and replicative stress responses.Cancer science · 2009Review
- Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.The Journal of biological chemistry · 2009Article
- Fhit tumor suppressor: guardian of the preneoplastic genome.Future oncology (London, England) · 2008Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The FHIT gene encompassing the most active common human chromosomal fragile region, FRA3B, was discovered in 1996 and proposed as a tumour suppressor gene for important human cancers. Seven years and more than 350 reports later, early questions concerning its tumour suppressor role have been answered. Recent studies on the role of Fhit loss in major types of human cancers report association with high proliferative and low apoptotic indices, node positivity, loss of mismatch repair protein, likelihood of progression and reduced survival.
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Registered trials
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