ArticleNucleic acids research2003
MALDI mass spectrometry analysis of single nucleotide polymorphisms by photocleavage and charge-tagging.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Evaluation of the Application of PCR and MALDI-TOF MS Methods for the Identification ofPathogens (Basel, Switzerland) · 2026Article
- Peptide nucleic acid probes with charged photocleavable mass markers: Towards PNA-based MALDI-TOF MS genetic analysis.Artificial DNA, PNA & XNA · 2010Article
- Association and linkage of allelic variants of the dopamine transporter gene in ADHD.Molecular psychiatry · 2007Article
- A matrix of 3,4-diaminobenzophenone for the analysis of oligonucleotides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Nucleic acids research · 2006Article
- Simultaneous genotyping of indels and SNPs by mass spectroscopy.Journal of the American Society for Mass Spectrometry · 2006Article
- Nucleic acid amplification-based techniques for pathogen detection and identification.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2006Review
- Rapid and accurate characterisation of short tandem repeats by MALDI-TOF analysis of endonuclease cleaved RNA transcripts.Nucleic acids research · 2004Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-throughput procedures are an important requirement for future large-scale genetic studies such as genotyping of single nucleotide polymorphisms (SNPs). Matrix-assisted laser desorption/ ionisation mass spectrometry (MALDI-MS) has revolutionised the analysis of biomolecules and, in particular, provides a very attractive solution for the rapid typing of DNA. The analysis of DNA by MALDI can be significantly facilitated by a procedure termed 'charge-tagging'. We show here a novel approach for the generation of charge-tagged DNA using a photocleavable linker and its implementation in a molecular biological procedure for SNP genotyping consisting of PCR, primer extension, photocleavage and a chemical reaction prior to MALDI target preparation and analysis. The reaction sequence is amenable to liquid handling automation and requires no stringent purification procedures. We demonstrate this new method on SNPs in two genes involved in complex traits.
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