ArticleThe British journal of ophthalmology2003
Architecture of arachnoid trabeculae, pillars, and septa in the subarachnoid space of the human optic nerve: anatomy and clinical considerations.
Article in The British journal of ophthalmology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 125 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Alveolar Recruitment Manoeuvre on Optic Nerve Sheath Diameter in Laparoscopic Hysterectomies
Effect of Needle Types and Diameters Using in Spinal Anesthesia on Optic Nerve Sheath Diameter; Prospective Randomized Study
Who cites it
125 citing papers in PubMed, 1 synthesis or guideline pooled it, 326 citations in OpenAlex.
- Orbital magnetic resonance imaging of giant cell arteritis with ocular manifestations: a systematic review and individual participant data meta-analysis.European radiology · 2023Pooled it
- Optic Nerve Subarachnoid Space Posture Dependency - An MRI Study in Subjects With Normal Tension Glaucoma and Healthy Controls.Investigative ophthalmology & visual science · 2023Trial
- Effects of sevoflurane and propofol on the optic nerve sheath diameter in patients undergoing laparoscopic gynecological surgery: a randomized controlled clinical studies.BMC anesthesiology · 2021Trial
- The impact of spinal cord nerve roots and denticulate ligaments on cerebrospinal fluid dynamics in the cervical spine.PloS one · 2014Trial
- Article
- Towards a Deeper Understanding of Cerebrospinal Fluid Transport in the Optic Nerve Subarachnoid Space: A Computational Approach.Annals of biomedical engineering · 2026Article
- A phantom mimicking layered biological microenvironments investigated with 7T diffusion weighted MRI.Scientific reports · 2026Article
- Non-invasive intracranial pressure estimation in the intensive care unit: narrative review of methods and clinical applications.Intensive care medicine · 2026Review
- Ophthalmologic assessment and intracranial pressure in children: diagnostic methods, clinical correlations, and future directions.Frontiers in pediatrics · 2026Review
- Derivative indices of optic nerve sheath diameter: a novel ultrasound-based approach for non-invasive intracranial pressure monitoring in neurocritical patients.Frontiers in neurology · 2026Article
- Leptomeninges: Anatomy, Mechanisms of Disease and Neuroimaging.Neurology international · 2025Review
- Ultrasound evaluation of the optic nerve in patients with severe symptomatic hyponatremia.Internal and emergency medicine · 2025Article
- Cervical Oculopathy: The Cervical Spine Etiology of Visual Symptoms and Eye Diseases-A Hypothesis Exploring Mechanisms Linking the Neck and the Eye.Diagnostics (Basel, Switzerland) · 2025Article
- Cervical Hyperextension Causes Acute Cerebral Congestion in Non-Anesthetized Healthy Adults: An Observational Self-Controlled Design Study.Medicina (Kaunas, Lithuania) · 2025Observational
- Experimental Analysis of Echogenic Signals Appearing in Optic Nerve Ultrasound.Neurocritical care · 2025Article
- A Novel Approach to Non-Invasive Intracranial Pressure Wave Monitoring: A Pilot Healthy Brain Study.Sensors (Basel, Switzerland) · 2025Article
- Spaceflight Associated Neuro-ocular Syndrome (SANS) and its countermeasures.Progress in retinal and eye research · 2025Review
- Deep learning based optic nerve sheath diameter characterization and structure quantification on transorbital ultrasound images.Frontiers in medicine · 2025Article
- Measuring optic nerve sheath diameter in children: a simple ultrasound protocol for ICP assessment.Frontiers in pediatrics · 2025Article
- Ultrasound-based measurement of optic nerve sheath to evaluate increased intracranial pressure on patients in emergency department.Frontiers in neurology · 2025Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo describe the anatomy and the arrangement of the arachnoid trabeculae, pillars, and septa in the subarachnoid space of the human optic nerve and to consider their possible clinical relevance for cerebrospinal fluid dynamics and fluid pressure in the subarachnoid space of the human optic nerve.
methodsPostmortem study with a total of 12 optic nerves harvested from nine subjects without ocular disease. All optic nerves used in this study were obtained no later than 7 hours after death, following qualified consent for necropsy. The study was performed with transmission (TEM) and scanning electron microscopy (SEM).
resultsThe subarachnoid space of the human optic nerve contains a variety of trabeculae, septa, and stout pillars that are arranged between the arachnoid and the pia layers of the meninges of the nerve. They display a considerable numeric and structural variability depending on their location within the different portions of the optic nerve. In the bulbar segment (ampulla), adjacent to the globe, a dense and highly ramified meshwork of delicate trabeculae is arranged in a reticular fashion. Between the arachnoid trabeculae, interconnecting velum-like processes are observed. In the mid-orbital segment of the orbital portion, the subarachnoid space is subdivided, and can appear even loosely chambered by broad trabeculae and velum-like septa at some locations. In the intracanalicular segment additionally, few stout pillars and single round trabeculae are observed.
conclusionThe subarachnoid space of the human optic nerve is not a homogeneous and anatomically empty chamber filled with cerebrospinal fluid, but it contains a complex system of arachnoid trabeculae and septa that divide the subarachnoid space. The trabeculae, septa, and pillars, as well as their arrangement described in this study, may have a role in the cerebrospinal fluid dynamics between the subarachnoid space of the optic nerve and the chiasmal cistern and may contribute to the understanding of the pathophysiology of asymmetric and unilateral papilloedema. All the structures described are of such delicate character that they can not even be visualised with high resolution magnetic resonance imaging (MRI).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.