ArticleThe British journal of ophthalmology2003
The clinical features of albinism and their correlation with visual evoked potentials.
Article in The British journal of ophthalmology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 84 citations in OpenAlex.
- Detecting congenital chiasmal misrouting using multichannel VEPs: protocol for a scoping review.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Can a Portable Flash Visual Evoked Potential (VEP) Device Identify Chiasmal Decussation Anomalies in Albinism?Diagnostics (Basel, Switzerland) · 2025Article
- Nystagmus in Clinical Practice: From Diagnosis to Treatment-A Comprehensive Review.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- Visual Performance of People With Albinism Assessed With Generalizable and Adaptive AIM and FInD Methods.Investigative ophthalmology & visual science · 2024Article
- Electrodiagnostic tests of the visual pathway and applications in neuro-ophthalmology.Eye (London, England) · 2024Review
- Article
- Tilted disc in eyes with fovea plana.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Article
- Phenotypic variations in ocular features among siblings with oculocutaneous albinism.Indian journal of ophthalmology · 2022Article
- Review
- Ophthalmological Manifestations of Oculocutaneous and Ocular Albinism: Current Perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2022Review
- Clinical electrophysiology of the optic nerve and retinal ganglion cells.Eye (London, England) · 2021Review
- Pattern-onset and OFFset visual evoked potentials in the diagnosis of hemianopic field defects.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- Identification of a novel GPR143 mutation in a large Chinese family with isolated foveal hypoplasia.BMC ophthalmology · 2021Article
- Retinal Vasoproliferative Tumor in Ocular Albinism.The American journal of case reports · 2020Article
- The relationship between retinal cone density and cortical magnification in human albinism.Journal of vision · 2020Article
- Occipital Petalia and Albinism: A Study of Interhemispheric VEP Asymmetries in Albinism with No Nystagmus.Journal of clinical medicine · 2019Article
- Comparison between albino and pigmented rabbit ERGs.Documenta ophthalmologica. Advances in ophthalmology · 2018Article
- Identification of a functionally significant tri-allelic genotype in the Tyrosinase gene (TYR) causing hypomorphic oculocutaneous albinism (OCA1B).Scientific reports · 2017Article
- Visual electrophysiology in the clinical evaluation of optic neuritis, chiasmal tumours, achiasmia, and ocular albinism: an overview.Documenta ophthalmologica. Advances in ophthalmology · 2014Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the relation between the clinical and electrophysiological abnormalities of patients undergoing visual evoked potential investigation for albinism.
methods40 subjects with a probable or possible clinical diagnosis of albinism underwent pattern appearance and/or flash visual evoked potential (VEP) examination. The VEP findings are correlated with the clinical features of albinism determined by clinical examination and orthoptic assessment.
resultsThe majority of patients with clinical evidence of albinism showed a contralateral predominance in the VEPs. There was close correlation between the clinical signs of albinism and the degree of contralateral VEP predominance. This manifested as an interhemispheric latency asymmetry to monocular pattern appearance stimulation but amplitude asymmetry to flash stimulation. The strongest correlation for pattern appearance interhemispheric latency difference was with foveal hypoplasia (rho = 0.58; p = 0.0003) followed by nystagmus (rho = 0.48; p = 0.0027) and iris transillumination (rho = 0.33; p = 0.039). The VEP abnormalities were of greater magnitude in those patients with most features of albinism. Several patients with apparently mild disorders of ocular pigmentation had small but significantly abnormal VEP latency asymmetries.
conclusionThere is a strong association between the magnitude of the interhemispheric latency asymmetry of the pattern appearance VEP, and of amplitude asymmetry of the flash VEP, with the clinical signs of albinism. The data are consistent with a spectrum of abnormalities in albinism involving both clinical expression and electrophysiological misrouting, which is wider than previously recognised.
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