ArticleBiophysical journal2003
Tonic and phasic receptor neurons in the vertebrate olfactory epithelium.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Immature olfactory sensory neurons are intrinsically excitable and show maturation-dependent changes in voltage-gated NaPflugers Archiv : European journal of physiology · 2026Article
- Shedding light on human olfaction: Electrophysiological recordings from sensory neurons in acute slices of olfactory epithelium.iScience · 2023Article
- Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation.Nature communications · 2018Article
- Ionic mechanisms underlying tonic and phasic firing behaviors in retinal ganglion cells: a model study.Channels (Austin, Tex.) · 2014Article
- Tonic signaling from O₂ sensors sets neural circuit activity and behavioral state.Nature neuroscience · 2012Article
- Functional asymmetries in cockroach ON and OFF olfactory receptor neurons.Journal of neurophysiology · 2011Article
- Precise and fuzzy coding by olfactory sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Dopamine reduces odor- and elevated-K(+)-induced calcium responses in mouse olfactory receptor neurons in situ.Journal of neurophysiology · 2004Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory receptor neurons (ORNs) respond to odorants with characteristic patterns of action potentials that are relevant for odor coding. Prolonged odorant exposures revealed three populations of dissociated toad ORNs, which were mimicked by depolarizing currents: tonic (TN, displaying sustained firing, 49% of 102 cells), phasic (PN, exhibiting brief action potential trains, 36%) and intermediate neurons (IN, generating trains longer than PN, 15%). We studied the biophysical properties underlying the differences between TNs and PNs, the most extreme cases among ORNs. TNs and PNs possessed similar membrane capacitances (approximately 4 pF), but they differed in resting potential (-82 versus -64 mV), input resistance (4.2 versus 2.9 G(Omega)) and unspecific current, I(u) (TNs: 0 < I(u) <or= 1 pA/pF; and PNs: I(u) > 1 pA/pF). Firing behavior did not correlate with differences in voltage-gated conductances. We developed a mathematical model that accurately simulates tonic and phasic patterns. Whole cell recordings from rat ORNs in fragments (approximately 4 mm(2)) of olfactory epithelium showed that such a tissue normally contains tonic and phasic receptor neurons, suggesting that this feature is common across a wide range of vertebrates. Our findings show that the individual passive electrical properties can govern the firing patterns of ORNs.
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