ArticleBiophysical journal2003
Unexpected mobility variation among individual secretory vesicles produces an apparent refractory neuropeptide pool.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis.The Journal of general physiology · 2018Review
- Segmentation of 3D Trajectories Acquired by TSUNAMI Microscope: An Application to EGFR Trafficking.Biophysical journal · 2016Article
- Synaptic neuropeptide release by dynamin-dependent partial release from circulating vesicles.Molecular biology of the cell · 2015Article
- Efficient copackaging and cotransport yields postsynaptic colocalization of neuromodulators associated with synaptic plasticity.Developmental neurobiology · 2008Article
- Signaling for vesicle mobilization and synaptic plasticity.Molecular neurobiology · 2008Review
- Increased motion and travel, rather than stable docking, characterize the last moments before secretory granule fusion.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Presynaptic ryanodine receptor-activated calmodulin kinase II increases vesicle mobility and potentiates neuropeptide release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Primed vesicles can be distinguished from docked vesicles by analyzing their mobility.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Analysis of transient behavior in complex trajectories: application to secretory vesicle dynamics.Biophysical journal · 2006Article
- Motion matters: secretory granule motion adjacent to the plasma membrane and exocytosis.Molecular biology of the cell · 2006Article
- Mechanisms of transport and exocytosis of dense-core granules containing tissue plasminogen activator in developing hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Three-dimensional tracking of single secretory granules in live PC12 cells.Biophysical journal · 2004Article
- A deeper look into single-secretory vesicle dynamics.Biophysical journal · 2004Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Most stored neuropeptide cannot be released from nerve terminals suggesting the existence of a refractory pool of dense core vesicles (DCVs). Past fluorescence photobleaching recovery, single particle tracking and release experiments suggested that the refractory neuropeptide pool corresponds to a distinct immobile fraction of cytoplasmic DCVs. However, tracking of hundreds of individual green fluorescent protein-labeled neuropeptidergic vesicles by wide-field or evanescent-wave microscopy shows that a separate immobile fraction is not evident. Instead, the DCV diffusion coefficient (D) distribution is unusually broad and asymmetric. Furthermore, the distribution shifts with a release facilitator. This unexpected variation, which could reflect heterogeneity among vesicles or in their medium, is shown to generate the appearance of a regulated refractory neuropeptide pool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.