ArticleBiophysical journal2003
Structural-functional relationships of the dynein, spokes, and central-pair projections predicted from an analysis of the forces acting within a flagellum.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 77 citations in OpenAlex.
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- Physiology and pathophysiology of human airway mucus.Physiological reviews · 2022Review
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- Diurnal Variations in the Motility of Populations of Biflagellate Microalgae.Biophysical journal · 2020Article
- Hydrodynamics of microbial filter feeding.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Central Apparatus of Cilia and Eukaryotic Flagella.Cold Spring Harbor perspectives in biology · 2017Review
- A computational model of dynein activation patterns that can explain nodal cilia rotation.Biophysical journal · 2015Article
- FAP206 is a microtubule-docking adapter for ciliary radial spoke 2 and dynein c.Molecular biology of the cell · 2015Article
- Article
- Motor regulation results in distal forces that bend partially disintegrated Chlamydomonas axonemes into circular arcs.Biophysical journal · 2014Article
- Protein tagging reveals new insights into signaling in flagella.The Journal of cell biology · 2014Article
- Cytotoxic effects of benzene metabolites on human sperm function: an in vitro study.ISRN toxicology · 2013Article
- The eukaryotic flagellum makes the day: novel and unforeseen roles uncovered after post-genomics and proteomics data.Current protein & peptide science · 2012Review
- Subunit interactions within the Chlamydomonas flagellar spokehead.Cytoskeleton (Hoboken, N.J.) · 2011Article
- Push-me-pull-you: how microtubules organize the cell interior.European biophysics journal : EBJ · 2008Review
- Insights into the mechanism of ADP action on flagellar motility derived from studies on bull sperm.Biophysical journal · 2008Article
- Bio-microrheology: a frontier in microrheology.Biophysical journal · 2006Review
- Cyclical interactions between two outer doublet microtubules in split flagellar axonemes.Biophysical journal · 2005Article
- Dimeric novel HSP40 is incorporated into the radial spoke complex during the assembly process in flagella.Molecular biology of the cell · 2005Article
- Diameter oscillation of axonemes in sea-urchin sperm flagella.Biophysical journal · 2004Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the axoneme of eukaryotic flagella the dynein motor proteins form crossbridges between the outer doublet microtubules. These motor proteins generate force that accumulates as linear tension, or compression, on the doublets. When tension or compression is present on a curved microtubule, a force per unit length develops in the plane of bending and is transverse to the long axis of the microtubule. This transverse force (t-force) is evaluated here using available experimental evidence from sea urchin sperm and bull sperm. At or near the switch point for beat reversal, the t-force is in the range of 0.25-1.0 nN/ micro m, with 0.5 nN/ micro m the most likely value. This is the case in both beating and arrested bull sperm and in beating sea urchin sperm. The total force that can be generated (or resisted) by all the dyneins on one micron of outer doublet is also approximately 0.5 nN. The equivalence of the maximum dynein force/ micro m and t-force/ micro m at the switch point may have important consequences. Firstly, the t-force acting on the doublets near the switch point of the flagellar beat is sufficiently strong that it could terminate the action of the dyneins directly by strongly favoring the detached state and precipitating a cascade of detachment from the adjacent doublet. Secondly, after dynein release occurs, the radial spokes and central-pair apparatus are the structures that must carry the t-force. The spokes attached to the central-pair projections will bear most of the load. The central-pair projections are well-positioned for this role, and they are suitably configured to regulate the amount of axoneme distortion that occurs during switching. However, to fulfill this role without preventing flagellar bend formation, moveable attachments that behave like processive motor proteins must mediate the attachment between the spoke heads and the central-pair structure.
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