ArticleBiophysical journal2003
Investigating the conformational states of the rabbit Na+/glucose cotransporter.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Simulated annealing reveals the kinetic activity of SGLT1, a member of the LeuT structural family.The Journal of general physiology · 2012Article
- Effects on conformational states of the rabbit sodium/glucose cotransporter through modulation of polarity and charge at glutamine 457.Biophysical journal · 2009Article
- Transmembrane IV of the high-affinity sodium-glucose cotransporter participates in sugar binding.American journal of physiology. Cell physiology · 2008Article
- Effect of substrate on the pre-steady-state kinetics of the Na(+)/glucose cotransporter.Biophysical journal · 2007Article
- Identification of a disulfide bridge linking the fourth and the seventh extracellular loops of the Na+/glucose cotransporter.The Journal of general physiology · 2006Article
- Perturbation analysis of the voltage-sensitive conformational changes of the Na+/glucose cotransporter.The Journal of general physiology · 2005Article
- Position 170 of Rabbit Na+/glucose cotransporter (rSGLT1) lies in the Na+ pathway; modulation of polarity/charge at this site regulates charge transfer and carrier turnover.Biophysical journal · 2004Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Na(+) and voltage-dependence of transient rabbit Na(+)/glucose cotransporter (rSGLT1) kinetics was studied with the two-electrode voltage-clamp technique and Xenopus laevis oocytes. Using step changes in membrane potential, in the absence of glucose but with 100 or 10 mM Na(+), transient currents were measured corresponding to binding/debinding of Na(+) and conformational changes of the protein. Previously, only a single time constant has been published for rSGLT1. We, however, observed three decay components; a fast (tau(f), 0.5-1 ms) voltage- and Na(+)-independent decay, and medium (tau(m), 0.5-4 ms) and slow (tau(s), 8-50 ms) voltage- and Na(+)-dependent decays. Transient currents were simulated and fit using a four-state model to obtain kinetic parameters for the system. The four-state model was able to reconstitute an assortment of experimental data.
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