ArticleBiophysical journal2003
Discrete models of autocrine cell communication in epithelial layers.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A computational framework to study EGFR signaling distribution in egg chambers during dynamic interactions between soma and germline.PLoS computational biology · 2025Article
- The role of cell geometry and cell-cell communication in gradient sensing.PLoS computational biology · 2022Article
- Simulation of Cell Patterning Triggered by Cell Death and Differential Adhesion in Drosophila Wing.Biophysical journal · 2018Article
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- Oscillatory flow accelerates autocrine signaling due to nonlinear effect of convection on receptor-related actions.Biophysical journal · 2013Article
- Effects of convective transport on chemical signal propagation in epithelia.Biophysical journal · 2012Article
- A mathematical model of intercellular signaling during epithelial wound healing.Journal of theoretical biology · 2010Article
- Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context.Molecular bioSystems · 2010Article
- Feedback control of the EGFR signaling gradient: superposition of domain-splitting events in Drosophila oogenesis.Development (Cambridge, England) · 2009Article
- From single cells to tissue architecture-a bottom-up approach to modelling the spatio-temporal organisation of complex multi-cellular systems.Journal of mathematical biology · 2009Article
- A combinatorial code for pattern formation in Drosophila oogenesis.Developmental cell · 2008Article
- Compensated optimal grids for elliptic boundary-value problems.Journal of computational physics · 2008Article
- Time and length scales of autocrine signals in three dimensions.Biophysical journal · 2007Article
- Microfluidic chip for fast bioassays-evaluation of binding parameters.Biomicrofluidics · 2007Article
- Quantifying the Gurken morphogen gradient in Drosophila oogenesis.Developmental cell · 2006Article
- Intercellular coupling amplifies fate segregation during Caenorhabditis elegans vulval development.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Emergent patterns of growth controlled by multicellular form and mechanics.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
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3 authors.
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Abstract
Pattern formation in epithelial layers heavily relies on cell communication by secreted ligands. Whereas the experimentally observed signaling patterns can be visualized at single-cell resolution, a biophysical framework for their interpretation is currently lacking. To this end, we develop a family of discrete models of cell communication in epithelial layers. The models are based on the introduction of cell-to-cell coupling coefficients that characterize the spatial range of intercellular signaling by diffusing ligands. We derive the coupling coefficients as functions of geometric, cellular, and molecular parameters of the ligand transport problem. Using these coupling coefficients, we analyze a nonlinear model of positive feedback between ligand release and binding. In particular, we study criteria of existence of the patterns consisting of clusters of a few signaling cells, as well as the onset of signal propagation. We use our model to interpret recent experimental studies of the EGFR/Rhomboid/Spitz module in Drosophila development.
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