ArticleJournal of human genetics2003
The medaka fish Tol2 transposable element can undergo excision in human and mouse cells.
Article in Journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 31 citations in OpenAlex.
- Complete fusion of a transposon and herpesvirus created the Teratorn mobile element in medaka fish.Nature communications · 2017Article
- DNA transposon-based gene vehicles - scenes from an evolutionary drive.Journal of biomedical science · 2013Review
- Efficient transposition of Tol2 in the mouse germline.Genetics · 2009Article
- Enzymatic engineering of the porcine genome with transposons and recombinases.BMC biotechnology · 2007Article
- Pigs taking wing with transposons and recombinases.Genome biology · 2007Review
- The Tol1 element of medaka fish is transposed with only terminal regions and can deliver large DNA fragments into the chromosomes.Journal of human genetics · 2007Article
- Harnessing a high cargo-capacity transposon for genetic applications in vertebrates.PLoS genetics · 2006Article
- Generating and manipulating transgenic animals using transposable elements.Reproductive biology and endocrinology : RB&E · 2003Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tol2 is an active DNA-based transposable element identified in the medaka fish, Oryzias latipes. Originating from a vertebrate and belonging to the hAT ( hobo/ Activator/ Tam3) transposable element family, featuring a wide distribution among organisms, Tol2 would be expected to be active if introduced into mammals. We, therefore, examined if excision, one part of the transposition reaction, can occur in human and mouse culture cells. A Tol2 clone was introduced into cells and, after incubation, recovered. PCR and sequencing analysis provided evidence for precise and near precise excision in these cells. Tol2 can thus be expected to serve as a material for developing a gene transfer vector and other genetic tools applicable to mammals. It was also suggested that an intact Tol2 element could retain autonomy as a transposable element in mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.