ArticleMolecular genetics and genomics : MGG2003
An Arabidopsis homologue of bacterial RecA that complements an E. coli recA deletion is targeted to plant mitochondria.
Article in Molecular genetics and genomics : MGG, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 62 citations in OpenAlex.
- A record-setting mitogenome in the holoparasitic plant Balanophora yakushimensis accompanied by exceptional loss of organellar DNA repair and recombination genes.BMC biology · 2025Article
- Chloroplastic RecA protein fromPhysiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- Mitochondrial DNA Repair in anPlants (Basel, Switzerland) · 2020Article
- Factors Affecting Organelle Genome Stability inPlants (Basel, Switzerland) · 2020Review
- Structure-Function Analysis Reveals the Singularity of Plant Mitochondrial DNA Replication Components: A Mosaic and Redundant System.Plants (Basel, Switzerland) · 2019Review
- Plant Organelle Genome Replication.Plants (Basel, Switzerland) · 2019Review
- Targeted expression of Vitreoscilla hemoglobin improves the production of tropane alkaloids in Hyoscyamus niger hairy roots.Scientific reports · 2018Article
- RECX Interacts with Mitochondrial RECA to Maintain Mitochondrial Genome Stability.Plant physiology · 2018Article
- Dynamic Interplay between Nucleoid Segregation and Genome Integrity in Chlamydomonas Chloroplasts.Plant physiology · 2016Article
- Evolution of bacterial recombinase A (recA) in eukaryotes explained by addition of genomic data of key microbial lineages.Proceedings. Biological sciences · 2016Article
- Minireview: DNA replication in plant mitochondria.Mitochondrion · 2014Review
- Mechanism of homologous recombination and implications for aging-related deletions in mitochondrial DNA.Microbiology and molecular biology reviews : MMBR · 2013Review
- RecA-dependent DNA repair results in increased heteroplasmy of the Arabidopsis mitochondrial genome.Plant physiology · 2012Article
- A conserved lysine residue of plant Whirly proteins is necessary for higher order protein assembly and protection against DNA damage.Nucleic acids research · 2012Article
- Identification of a soybean chloroplast DNA replication origin-binding protein.Plant molecular biology · 2011Article
- DNA repair and recombination in higher plants: insights from comparative genomics of Arabidopsis and rice.BMC genomics · 2010Article
- RecA maintains the integrity of chloroplast DNA molecules in Arabidopsis.Journal of experimental botany · 2010Article
- Implications of the plastid genome sequence of typha (typhaceae, poales) for understanding genome evolution in poaceae.Journal of molecular evolution · 2010Article
- Identification of mitochondrial genome concatemers in AIDS-associated lymphomas and lymphoid cell lines.Leukemia research · 2009Article
- Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks.The Journal of biological chemistry · 2009Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homologous recombination results in the exchange and rearrangement of DNA, and thus generates genetic variation in living organisms. RecA is known to function in all bacteria as the central enzyme catalyzing strand transfer and has functional homologues in eukaryotes. Most of our knowledge of homologous recombination in eukaryotes is limited to processes in the nucleus. The mitochondrial genomes of higher plants contain repeated sequences that are known to undergo frequent rearrangements and recombination events. However, very little is known about the proteins involved or the biochemical mechanisms of DNA recombination in plant mitochondria. We provide here the first report of an Arabidopsis thaliana homologue of Escherichia coli RecA that is targeted to mitochondria. The mt recA gene has a putative mitochondrial presequence identified from the A. thaliana genome database. This nuclear gene encodes a predicted product that shows highest sequence homology to chloroplast RecA and RecA proteins from proteobacteria. When fused to the GFP coding sequence, the predicted presequence was able to target the fusion protein to isolated mitochondria but not to chloroplasts. The mitochondrion-specific localization of the mt recA gene product was confirmed by Western analysis using polyclonal antibodies raised against a synthetic peptide from a unique region of the mature mtRecA. The Arabidopsis mt recA gene partially complemented a recA deletion in E. coli, enhancing survival after exposure to DNA-damaging agents. These results suggest a possible role for mt recA in homologous recombination and/or repair in Arabidopsis mitochondria.
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