ArticleMolecular genetics and genomics : MGG2003
ABC transporters of the wheat pathogen Mycosphaerella graminicola function as protectants against biotic and xenobiotic toxic compounds.
Article in Molecular genetics and genomics : MGG, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 74 citations in OpenAlex.
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- Rodents consuming the same toxic diet harbor a unique functional core microbiome.Animal microbiome · 2024Article
- GC-MS metabolite profiling of Pseudocercospora fijiensis isolates resistant to thiabendazole.PloS one · 2024Article
- The AbcCl1 transporter of Colletotrichum lindemuthianum acts as a virulence factor involved in fungal detoxification during common bean (Phaseolus vulgaris) infection.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Transitions of foliar mycobiota community and transcriptome in response to pathogenic conifer needle interactions.Scientific reports · 2022Article
- Disarming the Host: Detoxification of Plant Defense Compounds During Fungal Necrotrophy.Frontiers in plant science · 2021Review
- The host generalist phytopathogenic fungus Sclerotinia sclerotiorum differentially expresses multiple metabolic enzymes on two different plant hosts.Scientific reports · 2019Article
- Non-target site SDHI resistance is present as standing genetic variation in field populations of Zymoseptoria tritici.Pest management science · 2018Article
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- Identification and Regulation of Genes for Cobalamin Transport in the Cyanobacterium Synechococcus sp. Strain PCC 7002.Journal of bacteriology · 2016Article
- Transcriptional dynamics of Phytophthora infestans during sequential stages of hemibiotrophic infection of tomato.Molecular plant pathology · 2016Article
- Exploitation of sulfonylurea resistance marker and non-homologous end joining mutants for functional analysis in Zymoseptoria tritici.Fungal genetics and biology : FG & B · 2015Article
- Deciphering the role of phytoalexins in plant-microorganism interactions and human health.Molecules (Basel, Switzerland) · 2014Review
- Deoxynivalenol: a major player in the multifaceted response of Fusarium to its environment.Toxins · 2013Review
- The oxygenase CAO-1 of Neurospora crassa is a resveratrol cleavage enzyme.Eukaryotic cell · 2013Article
- Identification of ABC transporter genes of Fusarium graminearum with roles in azole tolerance and/or virulence.PloS one · 2013Article
- Overexpression of ShCYP51B and ShatrD in Sclerotinia homoeocarpa isolates exhibiting practical field resistance to a demethylation inhibitor fungicide.Applied and environmental microbiology · 2012Article
- Development of proteomics-based fungicides: new strategies for environmentally friendly control of fungal plant diseases.International journal of molecular sciences · 2011Review
- Mechanisms and significance of fungicide resistance.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied the role of five ABC transporter genes (MgAtr to MgAtr5) from the wheat pathogen Mycosphaerella graminicola in multidrug resistance (MDR). Complementation of Saccharomyces cerevisiae mutants with the ABC transporter genes from M. graminicola showed that all the genes tested encode proteins that provide protection against chemically unrelated compounds, indicating that their products function as multidrug transporters with distinct but overlapping substrate specificities. Their substrate range in yeast includes fungicides, plant metabolites, antibiotics, and a mycotoxin derived from Fusarium graminearum (diacetoxyscirpenol). Transformants of M. graminicola in which individual ABC transporter genes were deleted or disrupted did not exhibit clear-cut phenotypes, probably due to the functional redundancy of transporters with overlapping substrate specificity. Independently generated MgAtr5 deletion mutants of M. graminicola showed an increase in sensitivity to the putative wheat defence compound resorcinol and to the grape phytoalexin resveratrol, suggesting a role for this transporter in protecting the fungus against plant defence compounds. Bioassays with antagonistic bacteria indicated that MgAtr2 provides protection against metabolites produced by Pseudomonas fluorescens and Burkholderia cepacia. In summary, our results show that ABC transporters from M. graminicola play a role in protection against toxic compounds of natural and artificial origin.
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