ArticleJournal of virology2003
Functional characterization of the nuclear localization signal for a suppressor of posttranscriptional gene silencing.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 129 citations in OpenAlex.
- The divergent V2 protein encoded by parsley yellow leaf curl virus is a suppressor of transcriptional and post-transcriptional gene silencing and a potential symptom determinant.BMC plant biology · 2026Article
- In silico structural and disorder prediction of the tomato yellow leaf curl virus C2 protein and experimental assessment of subcellular localization and HR-like response.Journal of computer-aided molecular design · 2026Article
- Comparison of Tomato Yellow Leaf Curl Virus-Induced Gene Expression Pattern in Tomato and Tobacco Plants.The plant pathology journal · 2025Article
- Transcriptome and small RNAome profiling uncovers how a recombinant begomovirus evades RDRγ-mediated silencing of viral genes and outcompetes its parental virus in mixed infection.PLoS pathogens · 2024Article
- Sub-cellular localization of suppressor proteins of tomato leaf curl New Delhi virus.Virusdisease · 2021Article
- Targets and Mechanisms of Geminivirus Silencing Suppressor Protein AC2.Frontiers in microbiology · 2021Review
- p24Viruses · 2020Article
- Journey of begomovirus betasatellite molecules: from satellites to indispensable partners.Virus genes · 2020Review
- A Lysine Residue Essential for Geminivirus Replication Also Controls Nuclear Localization of the Tomato Yellow Leaf Curl Virus Rep Protein.Journal of virology · 2019Article
- Review
- The six Tomato yellow leaf curl virus genes expressed individually in tomato induce different levels of plant stress response attenuation.Cell stress & chaperones · 2017Article
- Article
- The C2 Protein from the Geminivirus Tomato Yellow Leaf Curl Sardinia Virus Decreases Sensitivity to Jasmonates and Suppresses Jasmonate-Mediated Defences.Plants (Basel, Switzerland) · 2016Article
- RNAi mediated broad-spectrum transgenic resistance in Nicotiana benthamiana to chilli-infecting begomoviruses.Plant cell reports · 2015Article
- Geminivirus protein structure and function.Molecular plant pathology · 2013Review
- How can plant DNA viruses evade siRNA-directed DNA methylation and silencing?International journal of molecular sciences · 2013Review
- Involvement of RDR6 in short-range intercellular RNA silencing in Nicotiana benthamiana.Scientific reports · 2012Article
- Genetic diversity of tomato-infecting Tomato yellow leaf curl virus (TYLCV) isolates in Korea.Virus genes · 2011Article
- Silencing of ORFs C2 and C4 of Tomato Yellow Leaf Curl Virus Engenders Resistant or Tolerant Plants.The open virology journal · 2011Article
- Roles of microRNA in plant defense and virus offense interaction.Plant cell reports · 2008Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleus-localized C2 protein of Tomato yellow leaf curl virus-China (TYLCV-C) is an active suppressor of posttranscriptional gene silencing (PTGS). Consistently, infection with TYLCV-C resulted in PTGS arrest in plants. The C2 protein possesses a functional, arginine-rich nuclear localization signal within the basic amino acid-rich region (17)KVQHRIAKKTTRRRR(31). When expressed from potato virus X, C2-RRRR(31)DVGG (in which the four consecutive arginine residues (28)RRRR(31) were replaced with DVGG) that had been tagged with a green fluorescent protein (GFP) failed to transport GFP into nuclei and was dysfunctional in inducing necrosis and suppressing PTGS in plants. Amino acid substitution mutants C2-K(17)D-GFP, C2-HR(21)DV-GFP, and C2-KK(25)DI-GFP localized to nuclei and produced necrosis, but only C2-K(17)D-GFP suppressed PTGS. The N-terminal portions C2(1-31) and C2(17-31) fused in frame to GFP were capable of targeting GFP to nuclei, but neither caused necrosis nor affected PTGS. Our data establish that nuclear localization is likely required for C2 protein to function in C2-mediated induction of necrosis and suppression of PTGS, which may follow diverse pathways in plants. Possible mechanisms of how the C2 protein involves these biological functions are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.