ArticleThe Journal of physiology2003
Alpha-adrenergic vascular responsiveness during postexercise hypotension in humans.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Acute Effect of Interval vs. Continuous Exercise on Blood Pressure: Systematic Review and Meta-Analysis.Arquivos brasileiros de cardiologia · 2020Pooled it
- Salt Loading Blunts Central and Peripheral Postexercise Hypotension.Medicine and science in sports and exercise · 2020Trial
- Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans.Experimental physiology · 2015Trial
- H1 receptor-mediated vasodilatation contributes to postexercise hypotension.The Journal of physiology · 2005Trial
- Circadian mechanisms underlying post-exercise blood pressure responses in healthy adults.Sleep · 2026Article
- Blood pressure response to exercise in children and adolescents.Frontiers in cardiovascular medicine · 2022Review
- Skeletal Muscle Hyperemia: A Potential Bridge Between Post-exercise Hypotension and Glucose Regulation.Frontiers in physiology · 2021Review
- Greater fluid loss does not fully explain the divergent hemodynamic balance mediating postexercise hypotension in endurance-trained men.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- The cardiovascular system after exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- Neurovascular control following small muscle-mass exercise in humans.Physiological reports · 2015Article
- Active and passive heat stress similarly compromise tolerance to a simulated hemorrhagic challenge.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Blood pressure regulation X: what happens when the muscle pump is lost? Post-exercise hypotension and syncope.European journal of applied physiology · 2014Review
- Aerobic interval exercise training induces greater reduction in cardiac workload in the recovery period in rats.Arquivos brasileiros de cardiologia · 2014Article
- Maintained cerebrovascular function during post-exercise hypotension.European journal of applied physiology · 2013Article
- Persistence of functional sympatholysis post-exercise in human skeletal muscle.Frontiers in physiology · 2013Article
- The influence of thermal factors on post-exercise haemodynamics in endurance exercise-trained men.The Journal of physiology · 2009Article
- Fluid replacement and heat stress during exercise alter post-exercise cardiac haemodynamics in endurance exercise-trained men.The Journal of physiology · 2009Article
- Ageing and leg postjunctional alpha-adrenergic vasoconstrictor responsiveness in healthy men.The Journal of physiology · 2007Article
- The anti-hypertensive effects of exercise: integrating acute and chronic mechanisms.Sports medicine (Auckland, N.Z.) · 2006Review
- Syncope during exercise, documented with continuous blood pressure monitoring during ergometer testing.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2005Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In sedentary individuals, postexercise hypotension following a single bout of aerobic exercise is due to an unexplained peripheral vasodilatation. We tested the hypothesis that alpha-adrenergic responsiveness in the forearm and leg vasculatures is blunted during postexercise hypotension. We studied 12 men and two women before and 30 min after a 60 min bout of cycling at 60 % VO2,peak. In the first five subjects, arterial pressure (brachial artery catheter) and forearm blood flow (plethysmography) were measured and vascular conductance was calculated during intraarterial infusions of the alpha1-agonist phenylephrine and the alpha2-agonist clonidine. Exercise reduced mean arterial pressure (89 +/- 2 vs. 95 +/- 2 mmHg, P < 0.05) and increased forearm vascular conductance 77 +/- 33 % (P < 0.05). Despite these changes in baseline vascular conductance, vasoconstrictor responses in the forearm to phenylephrine and clonidine were similar (or enhanced) postexercise vs. preexercise. In the remaining nine subjects, arterial pressure (femoral artery catheter) and leg blood flow (Doppler ultrasound of the femoral artery) were measured and vascular conductance was calculated during intraarterial infusions of phenylephrine and clonidine. Exercise reduced mean arterial pressure (80 +/- 2 vs. 89 +/- 2 mmHg, P < 0.05) and increased leg vascular conductance 94 +/- 16 % (P < 0.05). Despite these changes in baseline vascular conductance, vasoconstrictor responses in the leg to phenylephrine and clonidine were similar (or enhanced) postexercise vs. preexercise. These results suggest that vascular responsiveness to alpha-adrenergic agonists is maintained during postexercise hypotension in humans. Thus, while postexercise hypotension is associated with increased vascular conductance in the forearm and leg, it does not appear that blunting of alpha-adrenergic responsiveness is the cause.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.