Trial reportArchives of disease in childhood2003
Fluticasone propionate in asthma: a long term dose comparison study.
Trial report in Archives of disease in childhood, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Fluticasone at different doses for chronic asthma in adults and children.The Cochrane database of systematic reviews · 2008Pooled it
- Clinical safety of inhaled corticosteroids for asthma in children: an update of long-term trials.Drug safety · 2006Pooled it
- Systematic review of the dose-response relation of inhaled fluticasone propionate.Archives of disease in childhood · 2004Pooled it
- A Pilot Study of the Normative Range of Overnight Urinary Free Cortisol Corrected for Creatinine in Children.Clinical drug investigation · 2018Trial
- Efficacy and safety of fluticasone propionate/formoterol fumarate in pediatric asthma patients: a randomized controlled trial.Therapeutic advances in respiratory diseaseTrial
- Long-Term Fluticasone Propionate/Formoterol Fumarate Combination Therapy Is Associated with a Low Incidence of Severe Asthma Exacerbations.Journal of aerosol medicine and pulmonary drug delivery · 2016Article
- A transgenic zebrafish model for monitoring glucocorticoid receptor activity.Genes, brain, and behavior · 2014Article
- Adherence to preventive medications in asthmatic children at a tertiary care teaching hospital in Malaysia.Patient preference and adherence · 2014Article
- A copula model for marked point processes.Lifetime data analysis · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew dose ranging studies have investigated optimal dosing with inhaled corticosteroids in children with asthma.
aimsTo compare the efficacy and tolerability of fluticasone propionate 100 or 200 microg twice daily in children with moderate to severe asthma for one year.
methodsOne year, randomised, double blind, parallel group, multicentre study. Children aged 4-11 years (n = 528) with moderate to severe asthma who had previously received high dose inhaled corticosteroids were given fluticasone propionate 100 or 200 microg twice daily for the 52 week treatment period. Efficacy (exacerbations, lung function, and symptoms) and tolerability (adverse events and cortisol levels) were measured.
resultsThere was a non-significant decreased risk of experiencing an exacerbation at any time with fluticasone propionate 200 microg twice daily compared with fluticasone propionate 100 microg twice daily. This difference reached significance among patients with more severe asthma (defined by previous inhaled corticosteroid dose >800 microg/day). Daily record card morning peak expiratory flow (PEF) in the total population improved significantly more with the higher dose of fluticasone propionate (between group difference, weeks 1-52: 11.4 l/min). Clinic visit mean PEF improved from baseline with both doses, but the response was significantly greater with the higher dose (between group difference, week 52: 17.8 l/min). Both doses were equally well tolerated and overnight urinary cortisol concentrations were unchanged or slightly increased during treatment with either dose.
conclusionThis long term dose comparison study shows that treatment with fluticasone propionate 200 micro g twice daily may offer benefits over a lower dose, particularly in children with more severe asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.