ArticleJournal of human hypertension2003
Diarrhoea, vomiting and ACE inhibitors:--an important cause of acute renal failure.
Article in Journal of human hypertension, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- A new category for understanding the mechanisms of drug-induced kidney injury.Renal failure · 2025Review
- Using Human-Centered Design and Development to Create a Digital Sick Day Medication Guidance Application for People With Diabetes, Cardiovascular Disease, or Chronic Kidney Disease: Mixed Methods Study.JMIR formative research · 2025Article
- Medication management during risk of dehydration: A qualitative study among elderly patients with impaired renal function and informal caregivers.The European journal of general practice · 2024Article
- Characteristics and preventability of medication-related admissions for acute kidney injury and dehydration in elderly patients.European journal of clinical pharmacology · 2024Article
- Hospital admissions associated with dehydration in childhood kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2024Article
- Exposure to renin-angiotensin system inhibitors before kidney transplantation is associated with a decreased risk of delayed graft function.Frontiers in immunology · 2024Article
- Sick Day Medication Guidance for People With Diabetes, Kidney Disease, or Cardiovascular Disease: A Systematic Scoping Review.Kidney medicine · 2022Article
- Community prescribing of potentially nephrotoxic drugs and risk of acute kidney injury requiring renal replacement therapy in critically ill adults: A national cohort study.Journal of the Intensive Care Society · 2021Article
- Lithium Toxicity from the Addition of an ACE Inhibitor with an Unexpected Type I Brugada Pattern ECG: Case Files of the Medical Toxicology Fellowship at the University of California, San Diego.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2020Article
- Risk factors associated with biochemically detected and hospitalised acute kidney injury in patients prescribed renin angiotensin system inhibitors.British journal of clinical pharmacology · 2020Article
- Preventing acute kidney injury in high-risk patients by temporarily discontinuing medication - an observational study in general practice.BMC nephrology · 2019Observational
- In-vivo techniques for determining nephron number.Current opinion in nephrology and hypertension · 2019Review
- Acute Kidney Injury Due to Diarrheal Illness Requiring Hospitalization: Data from the National Inpatient Sample.Journal of general internal medicine · 2018Article
- Lower blood pressure and risk of cisplatin nephrotoxicity: a retrospective cohort study.BMC cancer · 2017Article
- Acute Kidney Injury in Elderly Patients With Chronic Kidney Disease: Do Angiotensin-Converting Enzyme Inhibitors Carry a Risk?Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Incidence of and risk factors for severe acute kidney injury in children with heart failure treated with renin-angiotensin system inhibitors.European journal of pediatrics · 2016Article
- Inhibition of RAS in diabetic nephropathy.International journal of nephrology and renovascular disease · 2015Review
- Prerenal uremia induced by severe diarrhea due to colon adenoma: a case of McKittrick-Wheelock syndrome in an elderly patient.CEN case reports · 2014Article
- Drug-induced gastrointestinal disorders.Frontline gastroenterology · 2014Review
- Preoperative use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers is associated with increased risk for acute kidney injury after cardiovascular surgery.Clinical journal of the American Society of Nephrology : CJASN · 2008Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The occurrence of severe acute renal failure in 3 patients who developed diarrhoea while taking angiotensin converting enzyme (ACE) inhibitors led us to undertake a retrospective cohort survey to determine the frequency with which diarrhoea and vomiting are associated with acute renal failure in patients taking this class of drug. Serum creatinine was measured as part of the diagnostic workup of 2398 consecutive admissions to an acute medical receiving unit in a district general hospital. Outcome measures were the presence of diarrhoea and/or vomiting, and whether taking an ACE inhibitor, NSAID or diuretic at the time of admission, also previous, initial and follow up serum creatinine concentrations. Peak serum creatinine in the 3 cases was 1159, 989 and 765 micromol/l. None of the 3 required dialysis and all recovered renal function completely after receiving large volumes of intravenous fluid. In the cohort study, 89 of 2398(3.7%) admissions had serum creatinine >/=200 micromol/l. Nine were regular dialysis patients. Of the remaining patients, 30 (37.5%) were taking an ACE inhibitor. Six of 30 (20%) gave a history of diarrhoea and/or vomiting. Median creatinine concentration in this group was 135 (range 111-209) micromol/l before admission, 292 (216-724) micromol/l when first seen in hospital, and 134 (94-219) micromol/l following the withdrawal of drug therapy and fluid replacement. In conclusion, volume depletion causing acute renal failure in patients taking ACE inhibitors is not uncommon. Such patients and their general practitioners should be aware that reversible renal impairment may occur during intercurrent illnesses, particularly if characterised by diarrhoea and/or vomiting.
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