ArticleLeukemia2003
Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development.
Article in Leukemia, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- HOXA9 versus HOXB9; particular focus on their controversial role in tumor pathogenesis.Journal of applied genetics · 2024Review
- Delineating the Immunotherapeutic Potential of Vitamin E and Its Analogues in Cancer: A Comprehensive Narrative Review.BioMed research international · 2024Review
- HOXB4 Mis-Regulation Induced by Microcystin-LR and Correlated With Immune Infiltration Is Unfavorable to Colorectal Cancer Prognosis.Frontiers in oncology · 2022Article
- Computational Identification of Master Regulators Influencing Trypanotolerance in Cattle.International journal of molecular sciences · 2021Article
- Gamma-tocotrienol modifies methylation of HOXA10, IRF4 and RORα genes in CD4Current research in immunology · 2021Article
- Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation.The Journal of experimental medicine · 2020Article
- IL-12 Signaling Contributes to the Reprogramming of Neonatal CD8Frontiers in immunology · 2020Article
- Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.Genome research · 2019Article
- Individual liver plasmacytoid dendritic cells are capable of producing IFNα and multiple additional cytokines during chronic HCV infection.PLoS pathogens · 2019Article
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- NKL homeobox gene activities in hematopoietic stem cells, T-cell development and T-cell leukemia.PloS one · 2017Article
- Specification and function of hemogenic endothelium during embryogenesis.Cellular and molecular life sciences : CMLS · 2016Review
- Upregulation of HOXB7 promotes the tumorigenesis and progression of gastric cancer and correlates with clinical characteristics.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
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- Epigenetic regulations in hematopoietic Hox code.Oncogene · 2011Review
- HoxA3 is an apical regulator of haemogenic endothelium.Nature cell biology · 2011Article
- A conserved role for Hox paralog group 4 in regulation of hematopoietic progenitors.Stem cells and development · 2009Article
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Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Class I homeobox (HOX) genes comprise a large family of transcription factors that have been implicated in normal and malignant hematopoiesis. However, data on their expression or function during T-cell development is limited. Using degenerated RT-PCR and Affymetrix microarray analysis, we analyzed the expression pattern of this gene family in human multipotent stem cells from fetal liver (FL) and adult bone marrow (ABM), and in T-cell progenitors from child thymus. We show that FL and ABM stem cells are similar in terms of HOX gene expression, but significant differences were observed between these two cell types and child thymocytes. As the most immature thymocytes are derived from immigrated FL and ABM stem cells, this indicates a drastic change in HOX gene expression upon entry into the thymus. Further analysis of HOX-A7, HOX-A9, HOX-A10, and HOX-A11 expression with specific RT-PCR in all thymocyte differentiation stages showed a sequential loss of 3' region HOX-A cluster genes during intrathymic T-cell development and an unexpected expression of HOX-A11, previously not recognized to play a role in hematopoiesis. Also HOX-B3 and HOX-C4 were expressed throughout thymocyte development. Overall, these data provide novel evidence for an important role of certain HOX genes in human T-cell development.
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