ArticleLeukemia2003
High frequency of pro-B acute lymphoblastic leukemia in adults with secondary leukemia with 11q23 abnormalities.
Article in Leukemia, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparative survival outcomes between therapy-related and de novo acute lymphoblastic leukemia in adults: a systematic review and meta-analysis.BMC cancer · 2025Pooled it
- Secondary acute lymphoblastic leukemia, a retrospective analysis from Washington University and meta-analysis of published data.Leukemia research · 2018Pooled it
- The potential role of environmentally associated DNA methylation in childhood acute lymphoblastic leukaemia subtypes.International journal of cancer · 2025Article
- A case of therapy-related acute lymphoblastic leukemia following the treatment of acute myeloid leukemia.Leukemia research reports · 2022Article
- Allogeneic Hematopoietic Stem Cell Transplantation in Therapy Related Acute Leukemia.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2021Review
- First reported case of secondary mixed phenotype acute leukemia after multiple myeloma.American journal of blood research · 2021Article
- Early induction and increased risk of precursor B-cell neoplasms after exposure of infant or young-adult mice to ionizing radiation.Journal of radiation research · 2020Article
- B-cell acute lymphoblastic leukemia as a secondary malignancy following diffuse large B-cell lymphoma.Hematology reports · 2019Article
- Evaluation of the Incidence of Hematologic Malignant Neoplasms Among Breast Cancer Survivors in France.JAMA network open · 2019Article
- Article
- Common B-cell acute lymphoblastic leukaemia in a 70-year-old woman presenting 2 years after carboplatin-taxane radiotherapy for endometrial cancer.Ecancermedicalscience · 2019Article
- Second primary acute lymphoblastic leukemia in adults: a SEER analysis of incidence and outcomes.Cancer medicine · 2018Article
- Secondary acute lymphoblastic leukemia is a distinct clinical entity with prognostic significance.Blood cancer journal · 2017Article
- Clonal evolution in therapy-related neoplasms.Oncotarget · 2017Article
- Therapy-related ALL: cytogenetic features and hematopoietic cell transplantation outcome.Bone marrow transplantation · 2015Article
- Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy: a unique case report.International journal of clinical and experimental pathology · 2014Review
- A focused review of hematopoietic neoplasms occurring in the therapy-related setting.International journal of clinical and experimental pathology · 2014Review
- Therapy-related pro-B cell acute lymphoblastic leukemia: report of two patients with MLL amplification.Cancer genetics · 2012Article
- Precursor B-acute lymphoblastic leukemia occurring in patients with a history of prior malignancies: is it therapy-related?Haematologica · 2012Article
- Secondary acute lymphoblastic leukaemia in a multiple myeloma patient.Contemporary oncology (Poznan, Poland) · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
To evaluate the frequency and cytogenetic and immunophenotypic features of therapy-related, precursor B-cell acute lymphoblastic leukemia (ALL), 152 cases of immature B-cell ALL were reviewed. These were compared to the frequency of therapy-related acute myeloid leukemia (t-AML) during the same time period. Eight ALL cases with a prior diagnosis of malignancy were identified, including six (4.0%) with prior therapy considered to be therapy-related ALL (t-ALL). The t-ALL cases followed treatment for breast carcinoma (two cases), lung carcinoma (two cases), lymphocyte predominance Hodgkin's disease and follicular lymphoma with a latency period of 13 months to 8 years. All t-ALL cases had a pro-B (CD10-negative) immunophenotype with significantly higher expression of CD15 and CD65, compared to the de novo CD10-positive ALL cases. All six t-ALL cases had MLL abnormalities by fluorescence in situ hybridization, and four showed t(4;11)(q21;q23). These represented half of all 11q23-positive adult ALL cases. During the same time period, 4.9% of all AML cases were considered t-AML. There was a 16.7% frequency of 11q23 abnormalities in the t-AML group. Despite the similar frequency in therapy-related disease among ALL and AML cases, there were differences in the frequency of the diseases and t-ALL represented 12% of all therapy-related leukemias. However, t-ALL represented 46% of all 11q23-positive therapy-related leukemias. The immunogenetic features of t-ALL appear distinct and may aid in identifying more cases of this disease type in the future.
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