ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Histological and electrical properties of rat dorsal root ganglion neurons innervating the lower urinary tract.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Article
- Pathways and parameters of sacral neuromodulation in rats.American journal of physiology. Renal physiology · 2023Article
- Selective recording of physiologically evoked neural activity in a mixed autonomic nerve using a minimally invasive array.APL bioengineering · 2023Article
- Article
- Bladder infection with uropathogenicAmerican journal of physiology. Renal physiology · 2022Article
- Computational modelling of nerve stimulation and recording with peripheral visceral neural interfaces.Journal of neural engineering · 2021Article
- Animal Model for Lower Urinary Tract Dysfunction in Parkinson's Disease.International journal of molecular sciences · 2020Review
- Role of p38 MAP kinase signaling pathways in storage and voiding dysfunction in mice with spinal cord injury.Neurourology and urodynamics · 2020Article
- Article
- A biophysically detailed computational model of urinary bladder small DRG neuron soma.PLoS computational biology · 2018Article
- Serotonergic paraneurones in the female mouse urethral epithelium and their potential role in peripheral sensory information processing.Acta physiologica (Oxford, England) · 2018Article
- New Frontiers of Basic Science Research in Neurogenic Lower Urinary Tract Dysfunction.The Urologic clinics of North America · 2017Review
- Electrophysiological properties of lumbosacral primary afferent neurons innervating urothelial and non-urothelial layers of mouse urinary bladder.Brain research · 2016Article
- Sensory neuron subpopulation-specific dysregulation of intracellular calcium in a rat model of chemotherapy-induced peripheral neuropathy.Neuroscience · 2015Article
- The effect of spinal cord injury on the neurochemical properties of vagal sensory neurons.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Neural control of the lower urinary tract.Comprehensive Physiology · 2015Review
- Developing a functional urinary bladder: a neuronal context.Frontiers in cell and developmental biology · 2015Review
- Somatomotor and sensory urethral control of micturition in female rats.American journal of physiology. Renal physiology · 2014Article
- Differential contribution of Kv4-containing channels to A-type, voltage-gated potassium currents in somatic and visceral dorsal root ganglion neurons.Journal of neurophysiology · 2014Article
- Distinct subclassification of DRG neurons innervating the distal colon and glans penis/distal urethra based on the electrophysiological current signature.Journal of neurophysiology · 2014Article
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Authors and funding
6 authors.
Funding
Abstract
We investigated whether primary afferent neurons innervating different regions of the lower urinary tract have different histochemical and electrophysiological properties. Neurons in rat L6-S1 DRG were identified by axonal transport of a fluorescent dye. Neurofilament-negative C-fiber cells comprise approximately 70% of bladder and proximal urethral afferent neurons that send axons through the pelvic nerves, but comprise a smaller proportion (51%) of distal urethral neurons that send axons through the pudendal nerves. Isolectin-B4 (IB4) binding was detected in a higher percentage (49%) of C-fiber neurons innervating the distal urethra than in those innervating the bladder or proximal urethra (18-22%). Neurofilament-positive A-fiber neurons innervating the distal urethra had a larger average somal size than neurons innervating the bladder or proximal urethra. In patch-clamp recordings, the majority (70%) of bladder and proximal urethral neurons were sensitive to capsaicin and exhibited TTX-resistant, high-threshold action potentials, whereas a smaller proportion (53%) of distal urethral neurons exhibited TTX-resistant spikes. T-type Ca2+ currents were observed in 47% of distal urethral neurons with TTX-sensitive spikes, but not in TTX-sensitive bladder or proximal urethral neurons. In summary, afferent neurons innervating bladder or proximal urethra differ from those innervating distal urethra. The latter, which more closely resemble cutaneous afferent neurons, consist of a smaller number of C-fiber neurons containing a higher percentage of IB4-positive cells and a more diverse population of A-fiber neurons, some of which exhibit T-type Ca2+ channels. These differences may be related to different functions of respective target organs in the lower urinary tract.
Indexed as
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12764124PMC6741085What OpenQuestion holds
Registered trials
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