ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Vasopressin differentially modulates non-NMDA receptors in vasopressin and oxytocin neurons in the supraoptic nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- Oestrogen inhibits salt-dependent hypertension by suppressing GABAergic excitation in magnocellular AVP neurons.Cardiovascular research · 2021Article
- Purinergic P2 and glutamate NMDA receptor coupling contributes to osmotically driven excitability in hypothalamic magnocellular neurosecretory neurons.The Journal of physiology · 2021Article
- Comparing vasopressin and oxytocin fiber and receptor density patterns in the social behavior neural network: Implications for cross-system signaling.Frontiers in neuroendocrinology · 2019Review
- Electrophysiological properties of identified oxytocin and vasopressin neurones.Journal of neuroendocrinology · 2019Review
- The Effects ofIranian journal of pharmaceutical research : IJPR · 2018Article
- GABAergic inhibition is weakened or converted into excitation in the oxytocin and vasopressin neurons of the lactating rat.Molecular brain · 2015Article
- Regulation of Neuronal Activity in Hypothalamic Vasopressin Neurons.Interdisciplinary information sciences · 2015Article
- Nutritional state-dependent ghrelin activation of vasopressin neurons via retrograde trans-neuronal-glial stimulation of excitatory GABA circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Physiological regulation of magnocellular neurosecretory cell activity: integration of intrinsic, local and afferent mechanisms.Journal of neuroendocrinology · 2013Review
- Multivesicular release underlies short term synaptic potentiation independent of release probability change in the supraoptic nucleus.PloS one · 2013Article
- Tonic regulation of GABAergic synaptic activity on vasopressin neurones by cannabinoids.Journal of neuroendocrinology · 2012Article
- Kainate receptor-induced retrograde inhibition of glutamatergic transmission in vasopressin neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- GABA is excitatory in adult vasopressinergic neuroendocrine cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Opposing actions of endothelin-1 on glutamatergic transmission onto vasopressin and oxytocin neurons in the supraoptic nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- ATP-sensitive potassium channel-mediated lactate effect on orexin neurons: implications for brain energetics during arousal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Acid-sensing ion channels in rat hypothalamic vasopressin neurons of the supraoptic nucleus.The Journal of physiology · 2010Article
- Central clock excites vasopressin neurons by waking osmosensory afferents during late sleep.Nature neuroscience · 2010Article
- TRPV1 gene deficiency attenuates miniature EPSC potentiation induced by mannitol and angiotensin II in supraoptic magnocellular neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task.PloS one · 2009Article
- Prolactin activates mitogen-activated protein kinase signaling and corticotropin releasing hormone transcription in rat hypothalamic neurons.Endocrinology · 2009Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnocellular neurons of the supraoptic nucleus release the neuropeptides oxytocin and vasopressin from their dendrites to regulate their synaptic inputs. This study aims to determine the cellular mechanism by which vasopressin modulates excitatory synaptic transmission. Presumably by electroporation through perforated patch, we were able to successfully introduce biocytin into cells in which we performed an electrophysiological study. This method enabled us to determine that roughly half of the recorded neurons were immunoreactive to oxytocin-associated neurophysin and showed two characteristic features: an inward rectification and a sustained outward rectification. The remaining half showed a linear voltage-current relationship and was immunoreactive to vasopressin-associated neurophysin. Using these electrophysiological characteristics and post hoc immunohistochemistry to identify vasopressin or oxytocin neurons, we found that vasopressin decreased evoked EPSCs in vasopressin neurons while increasing EPSCs in oxytocin neurons. In both types of neurons, EPSC decay constants were not affected, indicating that desensitization of non-NMDA receptors did not underlie the EPSC amplitude change. In vasopressin neurons, both vasopressin and a V1a receptor agonist, F-180, decreased AMPA-induced currents, an effect blocked by a V1a receptor antagonist SR49059. In oxytocin neurons, AMPA-induced currents were facilitated by vasopressin, whereas F-180 had no effect. An oxytocin receptor antagonist blocked the facilitatory effect of vasopressin. Thus, we conclude that vasopressin inhibits EPSCs in vasopressin neurons via postsynaptic V1a receptors, whereas it facilitates EPSCs in oxytocin neurons through oxytocin receptors.
Indexed as
Identifiers
12764115PMC6741118W1704281213What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.