Evidence map›Paper›PMID 12763753›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2003

Nucleotide coronary vasodilation in guinea pig hearts.

Mark W Gorman, Kayoko Ogimoto, Margaret V Savage, Kenneth A Jacobson, Eric O Feigl

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Disentangling the Gordian knot of local metabolic control of coronary blood flow.American journal of physiology. Heart and circulatory physiology · 2020
    Review
  3. Article
  4. Article
  5. Review
  6. Functional contribution of P2Y1 receptors to the control of coronary blood flow.Journal of applied physiology (Bethesda, Md. : 1985) · 2011
    Article
  7. Article
  8. Adenine nucleotide control of coronary blood flow during exercise.American journal of physiology. Heart and circulatory physiology · 2010
    Article
  9. Review
  10. Article
  11. Article
  12. ATP-loaded liposomes effectively protect mechanical functions of the myocardium from global ischemia in an isolated rat heart model.Journal of controlled release : official journal of the Controlled Release Society · 2005
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mark W GormanDepartment of Physiology and Biophysics, University of Washington School of Medicine, Box 357290, Seattle, WA 98195-7290, USA. mgorman@u.washington.edu
Kayoko Ogimoto
Margaret V Savage
Kenneth A Jacobson
Eric O Feigl
University of Washington · US

Funding

ADENOSINE &KATP CHANNEL CONTROL OF CORONARY BLOOD FLOWR01HL049822 · NHLBI · UNIVERSITY OF WASHINGTON · PI FEIGL, ERIC O · 1993 to 2005
$1.9M
PROSTHETIC GROUPS FOR RADIOLABELING OF FUNCTIONALIZED DRUGS AND PEPTIDESZ01DK031116 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 1991 to 2008
$769k
Intramural NIH HHS Z01 DK031116NHLBI NIH HHS HL 49822NHLBI NIH HHS R01 HL049822
6 · The paper itself

Abstract

The role of P1 receptors and P2Y1 receptors in coronary vasodilator responses to adenine nucleotides was examined in the isolated guinea pig heart. Bolus arterial injections of nucleotides were made in hearts perfused at constant pressure. Peak increase in flow was measured before and after addition of purinoceptor antagonists. Both the P1 receptor antagonist 8-(p-sulfophenyl)theophylline and adenosine deaminase inhibited adenosine vasodilation. AMP-induced vasodilation was inhibited by P1 receptor blockade but not by adenosine deaminase or by the selective P2Y1 antagonist N6-methyl-2'-deoxyadenosine 3',5'-bisphosphate (MRS 2179). ADP-induced vasodilation was moderately inhibited by P1 receptor blockade and greatly inhibited by combined P1 and P2Y1 blockade. ATP-induced vasodilation was antagonized by P1 blockade but not by adenosine deaminase. Addition of P2Y1 blockade to P1 blockade shifted the ATP dose-response curve further rightward. It is concluded that in this preparation ATP-induced vasodilation results primarily from AMP stimulation of P1 receptors, with a smaller component from ATP or ADP acting on P2Y1 receptors. ADP-induced vasodilation is largely due to P2Y1 receptors, with a smaller contribution by AMP or adenosine acting via P1 receptors. AMP responses are mediated solely by P1 receptors. Adenosine contributes very little to vasodilation resulting from bolus intracoronary injections of ATP, ADP, or AMP.

Indexed as

Adenine NucleotidesAdenosine DiphosphateAdenosine MonophosphateAdenosine TriphosphateAnimalsCoronary CirculationGuinea PigsMalePurinergic P1 Receptor AntagonistsPurinergic P2 Receptor AntagonistsReceptors, Purinergic P1Receptors, Purinergic P2Receptors, Purinergic P2Y1TheophyllineVasodilation8-(4-sulfophenyl)theophyllineAdenine NucleotidesAdenosine DiphosphateAdenosine MonophosphateAdenosine TriphosphateN(6)-methyl-2'-deoxyadenosine 3',5'-diphosphatePurinergic P1 Receptor AntagonistsPurinergic P2 Receptor AntagonistsReceptors, Purinergic P1Receptors, Purinergic P2Receptors, Purinergic P2Y1Theophylline

Identifiers

PMID12763753
PMCPMC8620194
OpenAlexW2092283786

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.