ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2003
Hypertrophy changes the muscarinic receptor subtype mediating bladder contraction from M3 toward M2.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 97 citations in OpenAlex.
- βNeurourology and urodynamics · 2025Review
- Pathophysiology of Overactive Bladder and Pharmacologic Treatments Including β3-Adrenoceptor Agonists -Basic Research Perspectives.International neurourology journal · 2024Article
- Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options.Drugs & aging · 2023Review
- Nerve transfer for restoration of lower motor neuron-lesioned bladder function. Part 1: attenuation of purinergic bladder smooth muscle contractions.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Normalization of organ bath contraction data for tissue specimen size: does one approach fit all?Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Reverse mode of sodium/calcium exchanger subtype 1 contributes to detrusor overactivity in rats with partial bladder outflow obstruction.American journal of translational research · 2018Article
- Increased expression of neuregulin 1 in the urothelium of rat bladder with partial bladder outlet obstruction.BMC urology · 2017Article
- Predictor of abnormal gallbladder ejection fraction in patients with atypical biliary pain: Histopathological point of view.Medicine · 2017Article
- Effects and Safety of Aqueous Extract ofEvidence-based complementary and alternative medicine : eCAM · 2016Article
- Research Findings on Overactive Bladder.Current urology · 2015Review
- Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms.BMC urology · 2015Article
- Does Decreased c-KIT Expression in Myenteric Interstitial Cells of Cajal Cause Decreased Spontaneous Contraction in Murine Proximal Colon?Journal of neurogastroenterology and motility · 2015Article
- Urinary Retention, Incontinence, and Dysregulation of Muscarinic Receptors in Male Mice Lacking Mras.PloS one · 2015Article
- Effects of bladder function by early tamsulosin treatment in a spinal cord injury rat model.Annals of rehabilitation medicine · 2014Article
- Gastric body cholinergic contractile signal transduction in M2 and M3 receptor knockout mice.Journal of receptor and signal transduction research · 2013Article
- Article
- Changes in the muscarinic receptors on the colonic smooth muscles of rats with spinal cord injury.Annals of rehabilitation medicine · 2011Article
- Temporal morphological and functional impact of complete urinary diversion on the bladder: a model of bladder disuse in rats.The Journal of urology · 2010Article
- The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder.The Journal of pharmacology and experimental therapeutics · 2010Article
- Impaired M3 and enhanced M2 muscarinic receptor contractile function in a streptozotocin model of mouse diabetic urinary bladder.Naunyn-Schmiedeberg's archives of pharmacology · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Major pelvic ganglion electrocautery (MPGE) and spinal cord injury in the rat induce bladder hypertrophy and a change in muscarinic receptor subtypes mediating bladder contraction from predominantly M3 to a combination of M2 and M3. To determine whether this is a result of bladder hypertrophy or denervation, we studied the following groups: sham-operated controls, urinary diversion (DIV), MPGE together with urinary diversion (DIV-DEN), bilateral MPGE (DEN), bladder outlet obstruction (BOO), and MPG decentralization (MPGDEC). The degree of bladder denervation was determined by the maximal carbachol response normalized to the response to electric field stimulation. Receptor subtype density was determined by immunoprecipitation. The affinity of subtype-selective muscarinic antagonists for inhibition of carbachol-induced contractions was used to determine the subtype-mediating contraction. DEN, MPG-DEC, and BOO bladders were hypertrophic whereas DIV bladders were atrophic compared with sham operated. Bladder contraction in sham-operated, DIV, and DIV-DEN was mediated by the M3 receptor subtype, whereas the M2 subtype participated in contraction in the DEN, MPG-DEC, and BOO groups. The hypertrophied bladders had an increase in total and M2 receptor density while all experimental groups showed a reduction in M3 receptor density. Thus bladder hypertrophy, independent from bladder denervation, causes a shift in the muscarinic receptor subtype mediating bladder contraction from M3 toward M2.
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