ArticleOncogene2003
Overexpression of the thymosin beta-4 gene is associated with malignant progression of SW480 colon cancer cells.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 75 citations in OpenAlex.
- Thymosin βCells · 2024Review
- A new prognostic model based on gamma-delta T cells for predicting the risk and aiding in the treatment of clear cell renal cell carcinoma.Discover oncology · 2024Article
- Acupuncture Regulates Serum Differentially Expressed Proteins in Patients with Chronic Atrophic Gastritis: A Quantitative iTRAQ Proteomics Study.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- TMSB10 acts as a biomarker and promotes progression of clear cell renal cell carcinoma.International journal of oncology · 2020Article
- Increased Expression of Thymosin βJournal of pathology and translational medicine · 2017Article
- Role of thymosin beta 4 in hair growth.Molecular genetics and genomics : MGG · 2016Article
- Thymosin β4 promotes hepatoblastoma metastasis via the induction of epithelial-mesenchymal transition.Molecular medicine reports · 2015Article
- Article
- Thymosin Beta-4, Actin-Sequestering Protein Regulates Vascular Endothelial Growth Factor Expression via Hypoxia-Inducible Nitric Oxide Production in HeLa Cervical Cancer Cells.Biomolecules & therapeutics · 2015Article
- In vivo growth suppression of CT-26 mouse colorectal cancer cells by adenovirus-expressed small hairpin RNA specifically targeting thymosin beta-4 mRNA.Cancer gene therapy · 2014Article
- Thymosin beta 4 and thymosin beta 10 expression in hepatocellular carcinoma.European journal of histochemistry : EJH · 2014Article
- Identification and validation of dysregulated metabolic pathways in metastatic renal cell carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- The actin-sequestering protein thymosin beta-4 is a novel target of hypoxia-inducible nitric oxide and HIF-1α regulation.PloS one · 2014Article
- Proteomic signatures of acquired letrozole resistance in breast cancer: suppressed estrogen signaling and increased cell motility and invasiveness.Molecular & cellular proteomics : MCP · 2013Article
- Thymosin ß4 expression in colorectal polyps and adenomas.Clinics (Sao Paulo, Brazil) · 2013Article
- Multiple functional involvement of thymosin beta-4 in tooth germ development.Histochemistry and cell biology · 2013Article
- β-thymosins and hemocyte homeostasis in a crustacean.PloS one · 2013Article
- Thymosin beta 4 expression in normal skin, colon mucosa and in tumor infiltrating mast cells.European journal of histochemistry : EJH · 2010Article
- Thymosin β4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma.Haematologica · 2010Article
- Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population.Stem cells (Dayton, Ohio) · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thymosin beta-4 (Tbeta-4), a small peptide originally isolated from calf thymus, modulates the formation of F-actin microfilaments by sequestering the monomeric G-actin. Recent studies have shown that overexpression of the Tbeta-4 gene occurs not only in many human carcinomas but also in the highly metastatic melanomas and fibrosarcomas. However, little is known about the specific growth advantages acquired by different tumors from this genetic abnormality. To address the above questions, Tbeta-4-overexpressing human colon carcinoma (SW480) cells were established by stable transfection and their phenotypic changes were monitored. We found that both the morphology and the cortical actin cytoskeleton of SW480 cells were altered by Tbeta-4 overexpression. Moreover, both cellular level and that distributed over the intercellular junctions of the E-cadherin were decreased in the Tbeta-4 overexpressers, which were accompanied by a twofold increase in their saturation densities. Meanwhile, these cells also exhibited an increased ability to form colonies in soft agar. Interestingly, a dramatic increase of growth rate was detected in the Tbeta-4 overexpressers, which might be attributed to an accelerated proliferation induced by c-Myc that was activated by nuclear beta-catenin. Finally, a motility increase of these cells was demonstrated by two independent migration assays, which was accompanied by an enhanced focal contact. Taken together, our data suggest that the drastic growth property and motility changes of the SW480 cells overexpressing Tbeta-4 gene are due mainly to a deregulated cell-cell adhesion arisen from the downregulation of E-cadherin, plus uncontrolled cell proliferation owing to the upregulation of beta-catenin, both resulted from a breakdown of actin microfilaments caused by the overexpression of this G-actin sequestering peptide.
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