ArticleInfection and immunity2003
Vaccine-induced protection against Helicobacter pylori in mice lacking both antibodies and interleukin-4.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 79 citations in OpenAlex.
- Mucosal vaccination with enzymatically activeFrontiers in microbiology · 2026Article
- Developing a potent vaccine againstExpert reviews in molecular medicine · 2024Review
- Article
- Article
- Synthetic Lipopeptide Enhances Protective Immunity AgainstFrontiers in immunology · 2019Article
- VacA's Induction of VacA-Containing Vacuoles (VCVs) and Their Immunomodulatory Activities on Human T Cells.Toxins · 2016Review
- Interferon-γ promotes gastric lymphoid follicle formation but not gastritis inGut pathogens · 2016Article
- Defining the Roles of IFN-γ and IL-17A in Inflammation and Protection against Helicobacter pylori Infection.PloS one · 2015Article
- Helicobacter pylori and T Helper Cells: Mechanisms of Immune Escape and Tolerance.Journal of immunology research · 2015Review
- Immune responses to Helicobacter pylori infection.World journal of gastroenterology · 2014Review
- Contribution of secretory antibodies to intestinal mucosal immunity against Helicobacter pylori.Infection and immunity · 2013Article
- Immunological response to parenteral vaccination with recombinant hepatitis B virus surface antigen virus-like particles expressing Helicobacter pylori KatA epitopes in a murine H. pylori challenge model.Clinical and vaccine immunology : CVI · 2012Article
- Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice.Mucosal immunology · 2012Article
- H. pylori exploits and manipulates innate and adaptive immune cell signaling pathways to establish persistent infection.Cell communication and signaling : CCS · 2011Article
- NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.The Journal of clinical investigation · 2010Article
- Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice.Gastroenterology · 2010Article
- Helicobacter pylori: bacterial factors and the role of cytokines in the immune response.Current microbiology · 2010Article
- Partial protection against Helicobacter pylori in the absence of mast cells in mice.Infection and immunity · 2009Article
- Antibody-mediated protection against infection with Helicobacter pylori in a suckling mouse model of passive immunity.Infection and immunity · 2009Article
- Effects of a Th1- versus a Th2-biased immune response in protection against Helicobacter pylori challenge in mice.Microbial pathogenesis · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
To test the hypothesis that a Th2 response to Helicobacter pylori is necessary for protection and to address the possibility that humoral and Th2 cellular responses may compensate for each other, we generated mice deficient in both interleukin-4 (IL-4) and antibodies. The immunized double-knockout mice were protected from H. pylori challenge, as were the parental strains and wild-type C57BL/6 mice. Neutralization of IL-4 in B-cell-deficient mice did not prevent protection. Immunized IL-5-deficient mice were also protected. Thus, IL-4 and IL-5 are not essential for protection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.