ArticleInfection and immunity2003
A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Structural insights into sigma class glutathione transferase from Taenia solium: Analysis and functional implications.PLoS neglected tropical diseases · 2025Article
- Detoxome Capacity of the Adult Rumen FlukeJournal of proteome research · 2025Article
- Biochemical characterization and gene structure analysis of the 24-kDa glutathione transferase sigma from Taenia solium.FEBS open bio · 2024Article
- Prostaglandin synthase activity of sigma- and mu-class glutathione transferases in a parasitic trematode, Clonorchis sinensis.Parasites, hosts and diseases · 2024Article
- Sigma-Class Glutathione Transferases (GSTσ): A New Target with Potential for Helminth Control.Tropical medicine and infectious disease · 2024Review
- Functional Diversity of the Excretory/Secretory Proteins of Nematode Parasites.Acta parasitologica · 2022Review
- Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions.European journal of immunology · 2021Review
- Mining nematode protein secretomes to explain lifestyle and host specificity.PLoS neglected tropical diseases · 2021Article
- Characterization of a novel glycosylated glutathione transferase ofParasitology · 2019Article
- Stage-specific Proteomes from Onchocerca ochengi, Sister Species of the Human River Blindness Parasite, Uncover Adaptations to a Nodular Lifestyle.Molecular & cellular proteomics : MCP · 2016Article
- The same or not the same: lineage-specific gene expansions and homology relationships in multigene families in nematodes.Journal of molecular evolution · 2015Article
- Harnessing the helminth secretome for therapeutic immunomodulators.BioMed research international · 2014Review
- Effect of Diethylcarbamazine (DEC) on prostaglandin levels in Wuchereria bancrofti infected microfilaraemics.Parasitology research · 2013Article
- The Sigma class glutathione transferase from the liver fluke Fasciola hepatica.PLoS neglected tropical diseases · 2012Article
- Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis.Chemical reviews · 2011Review
- Insulin/FOXO signaling regulates ovarian prostaglandins critical for reproduction.Developmental cell · 2010Article
- Molecular evidence for apoptosis in microfilariae of Wuchereria bancrofti induced by diethylcarbamazine.Parasitology research · 2008Article
- Regulatory cells and immunosuppressive cytokines: parasite-derived factors induce immune polarization.Journal of biomedicine & biotechnology · 2007Article
- Diethylcarbamazine activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway.Filaria journal · 2005Article
- The tapeworm Diphyllobothrium dendriticum (Cestoda) produces prostaglandin E2, a regulator of host immunity.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sectionsArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extracellular glutathione S-transferase from the filarial parasite Onchocerca volvulus (Ov-GST1) is a glutathione-dependent prostaglandin D synthase. Ov-GST1, located in the outer hypodermal lamellae and in parts of the cuticle, produces prostaglandin D(2) directly at the parasite-host interface. Ov-GST1 therefore has the potential to participate in the modulation of the host immune response by contributing to the production of prostanoids; this supports the predominant hypothesis that parasite-derived eicosanoids influence host inflammatory and immune cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.