ArticleInfection and immunity2003
The rovA mutant of Yersinia enterocolitica displays differential degrees of virulence depending on the route of infection.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Determinants of bacterial survival and proliferation in blood.FEMS microbiology reviews · 2024Review
- Kinetic Multi-omic Analysis of Responses to SARS-CoV-2 Infection in a Model of Severe COVID-19.Journal of virology · 2021Article
- Transcriptional Regulation Between the Two Global Regulators RovA and CRP in Yersinia pestis biovar Microtus.Current microbiology · 2018Article
- Reciprocal regulation of Yersinia pestis biofilm formation and virulence by RovM and RovA.Open biology · 2016Article
- Parallel independent evolution of pathogenicity within the genus Yersinia.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A direct link between the global regulator PhoP and the Csr regulon in Y. pseudotuberculosis through the small regulatory RNA CsrC.RNA biology · 2014Article
- YaxAB, a Yersinia enterocolitica pore-forming toxin regulated by RovA.Infection and immunity · 2013Article
- Molecular basis of Yersinia enterocolitica temperature-dependent resistance to antimicrobial peptides.Journal of bacteriology · 2012Article
- Mitogen-activated protein kinase-dependent interleukin-1α intracrine signaling is modulated by YopP during Yersinia enterocolitica infection.Infection and immunity · 2012Article
- Omics strategies for revealing Yersinia pestis virulence.Frontiers in cellular and infection microbiology · 2012Review
- Unique cell adhesion and invasion properties of Yersinia enterocolitica O:3, the most frequent cause of human Yersiniosis.PLoS pathogens · 2011Article
- Molecular characterization of transcriptional regulation of rovA by PhoP and RovA in Yersinia pestis.PloS one · 2011Article
- Transforming growth factor beta and CD25 are important for controlling systemic dissemination following Yersinia enterocolitica infection of the gut.Infection and immunity · 2010Article
- YopH inhibits early pro-inflammatory cytokine responses during plague pneumonia.BMC immunology · 2010Article
- Effect of flagellar mutations on Yersinia enterocolitica biofilm formation.Applied and environmental microbiology · 2008Article
- Comparative analysis of the regulation of rovA from the pathogenic yersiniae.Journal of bacteriology · 2007Article
- RovA, a global regulator of Yersinia pestis, specifically required for bubonic plague.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Histamine signaling through the H(2) receptor in the Peyer's patch is important for controlling Yersinia enterocolitica infection.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Characterization of oral Yersinia enterocolitica infection in three different strains of inbred mice.Infection and immunity · 2004Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Yersinia enterocolitica is an invasive enteric pathogen that causes significant inflammatory disease. Recently, we identified and characterized a global regulator of virulence (rovA). When mice are infected orally with the rovA mutant they are attenuated by 50% lethal dose (LD(50)) analysis and have altered kinetics of infection. Most significantly, mice orally infected with the rovA mutant have greatly reduced inflammation in the Peyer's patches compared to those infected with wild-type Y. enterocolitica. However, we present data here indicating that when the rovA mutant bacteria are delivered intraperitoneally (i.p.), they are significantly more virulent than when delivered orally. The i.p. LD(50) for the rovA mutant is only 10-fold higher than that of the wild-type Y. enterocolitica, and there are significant inflammatory responses to the rovA mutant that are evident in the liver and spleen. Altogether, these data suggest that the RovA regulon may be required for the early events of the infection that occur in the Peyer's patches. Furthermore, these data suggest that the RovA regulon may be dispensable for Y. enterocolitica systemic disease and inflammatory responses if the Peyer's patches are bypassed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.