ArticleInfection and immunity2003
Genetic diversity and antigenic polymorphism in Plasmodium falciparum: extensive serological cross-reactivity between allelic variants of merozoite surface protein 2.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed.
- Strain-specific humoral response to a polymorphic malaria vaccine.Infection and immunity · 2004Trial
- Evaluation of antibody serology to determine current helminth and Plasmodium falciparum infections in a co-endemic area in Southern Mozambique.PLoS neglected tropical diseases · 2022Article
- Antibody responses within two leading Plasmodium vivax vaccine candidate antigens in three geographically diverse malaria-endemic regions of India.Malaria journal · 2019Article
- Diversity and immune responses against Plasmodium falciparum gametocytes in non-febrile school children living in Southern Ghana.Malaria journal · 2019Article
- Immunogenicity analysis of genetically conserved segments in Plasmodium ovale merozoite surface protein-8.Parasites & vectors · 2019Article
- Article
- Multi-epitope chimeric antigen used as a serological marker to estimate Plasmodium falciparum transmission intensity in the border area of China-Myanmar.Infectious diseases of poverty · 2016Article
- Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic domains.Malaria journal · 2014Article
- Immunization with different PfAMA1 alleles in sequence induces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits.Malaria journal · 2011Article
- Article
- Evolutionary dynamics of the immunodominant repeats of the Plasmodium vivax malaria-vaccine candidate circumsporozoite protein (CSP).Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2010Article
- Allele-specific antibodies to Plasmodium falciparum merozoite surface protein-2 and protection against clinical malaria.Parasite immunology · 2010Article
- Sequence conservation in Plasmodium falciparum alpha-helical coiled coil domains proposed for vaccine development.PloS one · 2009Article
- Low density parasitaemia, red blood cell polymorphisms and Plasmodium falciparum specific immune responses in a low endemic area in northern Tanzania.BMC infectious diseases · 2009Article
- Effect of Plasmodium yoelii exposure on vaccination with the 19-kilodalton carboxyl terminus of merozoite surface protein 1 and vice versa and implications for the application of a human malaria vaccine.Infection and immunity · 2009Article
- Overuse of artemisinin-combination therapy in Mto wa Mbu (river of mosquitoes), an area misinterpreted as high endemic for malaria.Malaria journal · 2008Article
- Duration of naturally acquired antibody responses to blood-stage Plasmodium falciparum is age dependent and antigen specific.Infection and immunity · 2008Article
- Article
- In immunization with Plasmodium falciparum apical membrane antigen 1, the specificity of antibodies depends on the species immunized.Infection and immunity · 2007Article
- Antibodies elicited in adults by a primary Plasmodium falciparum blood-stage infection recognize different epitopes compared with immune individuals.Malaria journal · 2007Article
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Authors and funding
9 authors.
Funding
Abstract
Diversity in the surface antigens of malaria parasites is generally assumed to be a mechanism for immune evasion, but there is little direct evidence that this leads to evasion of protective immunity. Here we show that alleles of the highly polymorphic merozoite surface protein 2 (MSP-2) can be grouped (within the known dimorphic families) into distinct serogroups; variants within a serogroup show extensive serological cross-reactivity. Cross-reactive epitopes are immunodominant, and responses to them may be boosted at the expense of responses to novel epitopes (original antigenic sin). The data imply that immune selection explains only some of the diversity in the msp-2 gene and that MSP-2 vaccines may need to include only a subset of the known variants in order to induce pan-reactive antibodies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.