ArticleInfection and immunity2003
Neospora caninum-infected cattle develop parasite-specific CD4+ cytotoxic T lymphocytes.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- Immunization of cattle with live tachyzoites of Neospora caninum confers protection against fetal death.Infection and immunity · 2007Trial
- Review of neosporosis: Disease insights and control approaches.Open veterinary journal · 2025Review
- Article
- Flow Cytometric Analysis of the Cytotoxic T-Cell Recall Response toVeterinary sciences · 2021Article
- Maternal and Foetal Cellular Immune Responses in Dams Infected With High- and Low- Virulence Isolates ofFrontiers in cellular and infection microbiology · 2021Article
- From Signaling Pathways to Distinct Immune Responses: Key Factors for Establishing or CombatingPathogens (Basel, Switzerland) · 2020Review
- Immune response to Neospora caninum live tachyzoites in prepubertal female calves.Parasitology research · 2019Article
- Predominant role of interferon-γ in the host protective effect of CD8(+) T cells against Neospora caninum infection.Scientific reports · 2015Article
- Macrophage depletion prior to Neospora caninum infection results in severe neosporosis in mice.Clinical and vaccine immunology : CVI · 2014Article
- Development of maternal and foetal immune responses in cattle following experimental challenge with Neospora caninum at day 210 of gestation.Veterinary research · 2013Article
- Phenotypic characterisation of the cellular immune infiltrate in placentas of cattle following experimental inoculation with Neospora caninum in late gestation.Veterinary research · 2013Article
- Maternal and foetal immune responses of cattle following an experimental challenge with Neospora caninum at day 70 of gestation.Veterinary research · 2012Article
- Vaccines against a Major Cause of Abortion in Cattle, Neospora caninum Infection.Animals : an open access journal from MDPI · 2011Review
- Selection of Neospora caninum antigens stimulating bovine CD4+ve T cell responses through immuno-potency screening and proteomic approaches.Veterinary research · 2011Article
- Up regulation of the maternal immune response in the placenta of cattle naturally infected with Neospora caninum.PloS one · 2011Article
- T cell reactions of Eimeria bovis primary and challenge-infected calves.Parasitology research · 2010Article
- Upregulation of cytokines is detected in the placentas of cattle infected with Neospora caninum and is more marked early in gestation when fetal death is observed.Infection and immunity · 2008Article
- Bovine immune response to inoculation with Neospora caninum surface antigen SRS2 lipopeptides mimics immune response to infection with live parasites.Clinical and vaccine immunology : CVI · 2008Article
- The protozoan Neospora caninum directly triggers bovine NK cells to produce gamma interferon and to kill infected fibroblasts.Infection and immunity · 2006Article
- Cell-mediated protection in influenza infection.Emerging infectious diseases · 2006Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cattle infected with Neospora caninum readily experience transplacental parasite transmission, presumably after maternal parasitemia, leading to abortion or birth of congenitally infected calves. Cytotoxic T lymphocytes (CTL) are important mediators of protective immunity against Toxoplasma gondii, an intracellular apicomplexan protozoan closely related to N. caninum. In this study, N. caninum-specific CTL expanded from peripheral blood mononuclear cells of two major histocompatibility complex-mismatched, experimentally infected cattle were identified by using a (51)Cr release cytotoxicity assay. Enrichment and blocking of CD4(+)- and CD8(+)-T-lymphocyte effector subsets indicated that CD4(+) CTL killed N. caninum-infected, autologous target cells and that killing was mediated through a perforin/granzyme pathway. Detection and characterization of CTL responses to N. caninum in the natural, outbred, bovine host will facilitate identification of immunogens and design of immunization strategies to induce parasite-specific CTL against transplacental N. caninum transmission in cattle.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.