ArticleJournal of protein chemistry2003
Palindromes in proteins.
Article in Journal of protein chemistry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 26 citations in OpenAlex.
- WAS IT A MATch I SAW? Approximate palindromes lead to overstated false match rates in benchmarks using reversed sequences.Bioinformatics advances · 2024Article
- Palindromic Vectors, Symmetropy and Symmentropy as Symmetry Descriptors of Binary Data.Entropy (Basel, Switzerland) · 2022Article
- Analyses of the Sequence and Structural Properties Corresponding to Pentapeptide and Large Palindromes in Proteins.PloS one · 2015Article
- PPS: A computing engine to find Palindromes in all Protein sequences.Bioinformation · 2014Article
- An algorithm to find all palindromic sequences in proteins.Journal of biosciences · 2013Article
- Palindromes drive the re-assortment in Influenza A.Bioinformation · 2011Article
- A tale of two symmetrical tails: structural and functional characteristics of palindromes in proteins.BMC bioinformatics · 2008Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Palindromes in DNA consist of nucleotides sequences that read the same from the 5'-end to the 3'-end, and its double helix is related by twofold axis. They occur in genomes of all organisms and have various functions. For example, restriction enzymes often recognize palindromic sequences of DNA. Palindromes in telomeres are crucial for initiation of replication. One can ask the questions, Do palindromes occur in protein, and if so, what function they play? We have searched the protein SWISSPROT database for palindromic sequences. A great number (26%) of different protein palindromes were found. One example of such protein is systemin, an 18-amino-acid-long peptide. It contains palindrome in its beta-sheet domain that interacts with palindromic fragment of DNA. The other palindrome containing protein is cellular human tumor suppressor p53. Oligonucleotide LTI-ITL has been observed in the crystal structure and is located close to a DNA recognizing domain. As the number of possible palindromic sequences of a given length is far much greater for proteins (20N) than for nucleic acids (4N), the study on their role seems to be an exciting challenge. Our results have clearly showed that palindromes are frequently occurring motives in proteins. Moreover, even very few examples that we have examined so far indicate the importance of further studies on protein palindromes.
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Registered trials
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