ArticleVirchows Archiv : an international journal of pathology2003
Altered expression of desmosomal components in high-grade squamous intraepithelial lesions of the cervix.
Article in Virchows Archiv : an international journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Genetic Factors Involved in Cardiomyopathies and in Cancer.Journal of clinical medicine · 2020Review
- Improvement of Storage Medium for Cultured Human Retinal Pigment Epithelial Cells Using Factorial Design.Scientific reports · 2018Article
- Aberrant expression and altered cellular localization of desmosomal and hemidesmosomal proteins are associated with aggressive clinicopathological features of oral squamous cell carcinoma.Virchows Archiv : an international journal of pathology · 2014Article
- Desmoglein-3/γ-catenin and E-cadherin/ß-catenin differential expression in oral leukoplakia and squamous cell carcinoma.Clinical oral investigations · 2014Article
- Expression of DSG1 and DSC1 are prognostic markers in anal carcinoma patients.British journal of cancer · 2012Article
- Desmosomes: new perpetrators in tumour suppression.Nature reviews. Cancer · 2011Review
- E7 oncoprotein of novel human papillomavirus type 108 lacking the E6 gene induces dysplasia in organotypic keratinocyte cultures.Journal of virology · 2009Article
- Desmoglein 2 is a substrate of kallikrein 7 in pancreatic cancer.BMC cancer · 2008Article
- Article
- Altered expression of desmocollin 3, desmoglein 3, and beta-catenin in oral squamous cell carcinoma: correlation with lymph node metastasis and cell proliferation.Virchows Archiv : an international journal of pathology · 2007Article
- Plakoglobin suppresses keratinocyte motility through both cell-cell adhesion-dependent and -independent mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used immunohistochemistry to test the hypothesis that components of the desmosome are disrupted during neoplastic progression of squamous epithelial cells in the uterine cervix. Sections of normal cervix and squamous intraepithelial lesions (SILs) were immunostained for desmosomal proteins and glycoproteins, and results were assessed using a semi-quantitative grading system. No difference between normal cervix and low-grade SIL (LSIL) was found. A significant reduction in expression of desmogleins was seen between high-grade SIL (HSIL) and LSIL (P<0.01) and normal cervix (P<0.001). Desmocollin expression was not reduced significantly, although scores showed significantly greater variation in HSIL compared with LSIL (P<0.05) and normal cervix (P<0.05). There was no significant difference in desmoplakin expression among the three groups. The results suggest that there may be sequential disruption of desmosomal function during neoplastic progression of cervical squamous intraepithelial cells, with downregulation of desmogleins during the progression from LSIL to HSIL and loss of desmocollin expression occurring in some cases of established HSIL.
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