ArticleThe American journal of pathology2003
Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 50 citations in OpenAlex.
- m6A RNA methylation modulates antiviral response in celiac disease.Genes and immunity · 2026Article
- Immune cell dynamics and mechanisms of epithelial injury in celiac disease.Frontiers in immunology · 2026Review
- Proteins from Modern and Ancient Wheat Cultivars: Impact on Immune Cells of Healthy Individuals and Patients with NCGS.Nutrients · 2022Article
- Characterisation of gene and pathway expression in stabilised blood from children with coeliac disease.BMJ open gastroenterology · 2020Article
- A Driver Never Works Alone-Interplay Networks of Mutant p53, MYC, RAS, and Other Universal Oncogenic Drivers in Human Cancer.Cancers · 2020Review
- A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation.Scientific reports · 2019Article
- In the Intestinal Mucosa of Children With Potential Celiac Disease IL-21 and IL-17A are Less Expressed than in the Active Disease.The American journal of gastroenterology · 2016Article
- Effector and suppressor T cells in celiac disease.World journal of gastroenterology · 2015Review
- Review
- PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.Diabetes · 2011Article
- Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier.PloS one · 2011Article
- Convergence of hormones, inflammation, and energy-related factors: a novel pathway of cancer etiology.Cancer prevention research (Philadelphia, Pa.) · 2009Review
- T-bet and pSTAT-1 expression in PBMC from coeliac disease patients: new markers of disease activity.Clinical and experimental immunology · 2009Article
- Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa.Gut · 2004Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biological effects of interferon (IFN)-gamma rely mainly on the activity of the transcription factor signal transducer and activator of transcription (STAT) 1 and the intracellular levels of suppressor of cytokine signaling (SOCS)-1, a negative regulator that controls the amplitude and duration of STAT-1 activation. IFN-gamma is a key mediator of the immunopathology in celiac disease (CD, gluten-sensitive enteropathy). Thus we have investigated STAT-1 signaling and SOCS-1 expression in this condition. As expected, high local concentrations of IFN-gamma were invariably seen in duodenal biopsies from CD patients in comparison to controls. On the basis of immunohistochemistry, STAT-1 phosphorylation, nuclear localization, and DNA-binding activity, STAT-1 activation was consistently more pronounced in CD compared with controls. Despite samples from CD patients containing abundant SOCS-1 mRNA, SOCS-1 protein was expressed at the same level in CD patients and controls. In explant cultures of CD biopsies, gliadin induced the activation of STAT-1 but not SOCS-1. Furthermore, inhibition of STAT-1 prevented the gliadin-mediated induction of ICAM-1 and B7-2. These data suggest that persistent STAT-1 activation can contribute to maintaining and expanding the local inflammatory response in CD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.