ArticleJournal of molecular biology2003
Functional interplay between CBP and PCAF in acetylation and regulation of transcription factor KLF13 activity.
Article in Journal of molecular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- KLF13-mediated CES2 upregulation via p300-dependent acetylation sensitizes gastric cancer cells to irinotecan.iScience · 2025Article
- Bioinformatic Evaluation ofGenes · 2024Article
- The histone lysine acetyltransferase KAT2B inhibits cholangiocarcinoma growth: evidence for interaction with SP1 to regulate NF2-YAP signaling.Journal of experimental & clinical cancer research : CR · 2024Article
- Review
- Article
- Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant Tumors.Frontiers in cell and developmental biology · 2021Review
- The regulation of acetylation and stability of HMGA2 via the HBXIP-activated Akt-PCAF pathway in promotion of esophageal squamous cell carcinoma growth.Nucleic acids research · 2020Article
- Downregulation of KLF13 through DNMT1-mediated hypermethylation promotes glioma cell proliferation and invasion.OncoTargets and therapy · 2019Article
- Krüppel-like factors: Crippling and un-crippling metabolic pathways.JACC. Basic to translational science · 2018Article
- Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT.Journal of structural and functional genomics · 2015Article
- KLF13 promotes porcine adipocyte differentiation through PPARγ activation.Cell & bioscience · 2015Article
- Epigenetic regulation of axon outgrowth and regeneration in CNS injury: the first steps forward.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2013Review
- Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner.The Journal of biological chemistry · 2012Article
- Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells.The Journal of biological chemistry · 2012Article
- Article
- Poly(ADP-ribose) polymerase-1 (PARP-1) contributes to the barrier function of a vertebrate chromatin insulator.The Journal of biological chemistry · 2010Article
- KLF8 recruits the p300 and PCAF co-activators to its amino terminal activation domain to activate transcription.Cell cycle (Georgetown, Tex.) · 2010Article
- Human Krüppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells.Diabetologia · 2007Article
- Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The transcriptional co-activators CBP/p300 and PCAF participate in transcriptional activation by many factors. We have shown that both CBP/p300 and PCAF stimulate the transcriptional activation by KLF13, a member of the KLF/Sp1 family, either individually or cooperatively. Here we further investigated how CBP and PCAF acetylation regulate KLF13 activity, and how these two co-activators functionally interplay in the regulation of KLF13 activity. We found that CBP and PCAF acetylated KLF13 at specific lysine residues in the zinc finger domain of KLF13. The acetylation by CBP, however, resulted in disruption of KLF13 DNA binding. Although the acetyltransferase activity of CBP is not required for stimulating the DNA binding activity of all of the transcription factors that we have examined, the disruption of factor DNA binding by CBP acetylation is factor-specific. We further showed that PCAF and CBP act synergistically and antagonistically to regulate KLF13 DNA binding depending on the status of acetylation. PCAF blocked CBP acetylation and disruption of KLF13 DNA binding. Conversely, acetylation of KLF13 by CBP prevented PCAF stimulation of KLF13 DNA binding. PCAF blocked CBP disruption of KLF13 DNA binding by preventing CBP acetylation of KLF13. These results demonstrate that acetylation by CBP has distinct effects on transcription factor DNA binding, and that CBP and PCAF regulate each other functionally in their regulation of transcription factor DNA binding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.