Evidence map›Paper›PMID 12756415›Full record

ReviewGene therapy2003

Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences.

P R Lowenstein, M G Castro

Abstract readReview
PubMed Publisher
In one paragraph

Review in Gene therapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Gene Therapy Tools for Brain Diseases.Frontiers in pharmacology · 2019
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Gene therapy for Parkinson's disease.Parkinson's disease · 2012
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

P R LowensteinGene Therapeutics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
M G Castro

Funding

Trophic gene transfer in MPTP animalsU54NS045309 · NINDS · UNIVERSITY OF ROCHESTER · PI FEDEROFF, HOWARD J. · 2002 to 2006
$9.7M
Gene therapy for chronic neurodegenerative disordersR01NS044556 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI CASTRO, MARIA G · 2002 to 2006
$2.0M
Gene Therapy for Neurological DiseasesR01NS042893 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI LOWENSTEIN, PEDRO R · 2002 to 2006
$1.8M
NINDS NIH HHS 1 R01 NS 42893 01NINDS NIH HHS 1 R01 NS44556 01NINDS NIH HHS U54 4 NS04-5309
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdenoviridaeAdenoviridae InfectionsAnimalsAntigens, ViralBrainCytokinesEncephalitisGenetic TherapyGenetic VectorsHumansInjections, IntraventricularT-LymphocytesViral Envelope ProteinsAntigens, ViralCytokinesViral Envelope Proteins

Identifiers

PMID12756415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.