ArticleThe Journal of cell biology2003
Macrophage podosomes assemble at the leading lamella by growth and fragmentation.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- Human XIRP1 is a new podosome protein targeting cytosolic bacteria as part of the IFN-γ defense program.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Ectromelia Virus Affects the Formation and Spatial Organization of Adhesive Structures in Murine Dendritic Cells In Vitro.International journal of molecular sciences · 2023Article
- Microglia degrade Tau oligomers deposit via purinergic P2Y12-associated podosome and filopodia formation and induce chemotaxis.Cell & bioscience · 2023Article
- Efficient T Cell Migration and Activation Require L-Plastin.Frontiers in immunology · 2022Review
- Novel Mouse Model Reveals That Serine Phosphorylation of L-Plastin Is Essential for Effective Splenic Clearance of Pneumococcus.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Elucidating the Biomechanics of Leukocyte Transendothelial Migration by Quantitative Imaging.Frontiers in cell and developmental biology · 2021Review
- Transition of podosomes into zipper-like structures in macrophage-derived multinucleated giant cells.Molecular biology of the cell · 2020Article
- The surface stress of biomedical silicones is a stimulant of cellular response.Science advances · 2020Article
- S100A4 regulates macrophage invasion by distinct myosin-dependent and myosin-independent mechanisms.Molecular biology of the cell · 2018Article
- Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking.Nature communications · 2018Article
- Roles of Macrophage Exosomes in Immune Response to Calcium Oxalate Monohydrate Crystals.Frontiers in immunology · 2018Article
- Super-Resolution Correlative Light and Electron Microscopy (SR-CLEM) Reveals Novel Ultrastructural Insights Into Dendritic Cell Podosomes.Frontiers in immunology · 2018Article
- Symmetrical retrograde actin flow in the actin fusion structure is involved in osteoclast fusion.Biology open · 2017Article
- Dynamics of the sealing zone in cultured osteoclasts.Cytoskeleton (Hoboken, N.J.) · 2017Article
- Alveolar macrophage development in mice requires L-plastin for cellular localization in alveoli.Blood · 2016Article
- Actomyosin-dependent dynamic spatial patterns of cytoskeletal components drive mesoscale podosome organization.Nature communications · 2016Article
- L-Plastin promotes podosome longevity and supports macrophage motility.Molecular immunology · 2016Article
- Regulation of cell-cell fusion by nanotopography.Scientific reports · 2016Article
- Metalloproteinase MT1-MMP islets act as memory devices for podosome reemergence.The Journal of cell biology · 2016Article
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Podosomes are actin- and fimbrin-containing adhesions at the leading edge of macrophages. In cells transfected with beta-actin-ECFP and L-fimbrin-EYFP, quantitative four-dimensional microscopy of podosome assembly shows that new adhesions arise at the cell periphery by one of two mechanisms; de novo podosome assembly, or fission of a precursor podosome into daughter podosomes. The large podosome cluster precursor also appears to be an adhesion structure; it contains actin, fimbrin, integrin, and is in close apposition to the substratum. Microtubule inhibitors paclitaxel and demecolcine inhibit the turnover and polarized formation of podosomes, but not the turnover rate of actin in these structures. Because daughter podosomes and podosome cluster precursors are preferentially located at the leading edge, they may play a critical role in continually generating new sites of cell adhesion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.