ArticleProceedings of the National Academy of Sciences of the United States of America2003
Adrenergic regulation of clock gene expression in mouse liver.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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Who cites it
92 citing papers in PubMed, 286 citations in OpenAlex.
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- Circadian Activity Disruption in Cardiac Remodeling Patients Underlies Autonomic Dysfunction in Heart Failure.Biomedicines · 2026Article
- Adrenaline restores Bmal1 transcriptional rhythms dampened by SARS-CoV-2 infection in Cthrc1-positive pulmonary fibroblasts derived from the Nile grass rat.Scientific reports · 2026Article
- Physical exercise as a modulator of the sleep-obesity interaction: metabolic, neuroendocrine and circadian mechanisms.Frontiers in sleep · 2026Review
- Chronic Restraint Stress Misaligns Corneal Clock via β-Adrenergic and Glucocorticoid Signaling, Altering Epithelial, Neural, Immune, Metabolic States.Investigative ophthalmology & visual science · 2025Article
- Hijacking homeostasis: the brain-body neural circuitry in tumor pathogenesis and emerging therapeutic frontiers.Molecular cancer · 2025Review
- Circadian clock communication during homeostasis and ageing.Nature reviews. Molecular cell biology · 2025Review
- Sweetened caffeine drinking revealed behavioral rhythm independent of the central circadian clock in male mice.NPJ science of food · 2024Article
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- Interorgan rhythmicity as a feature of healthful metabolism.Cell metabolism · 2024Review
- Prostaglandin F2α Affects the Cycle of Clock Gene Expression and Mouse Behavior.International journal of molecular sciences · 2024Article
- Application and limitation of a biological clock-based method for estimating time of death in forensic practices.Scientific reports · 2023Article
- Glucocorticoids coordinate the bladder peripheral clock and diurnal micturition pattern in mice.Communications biology · 2023Article
- Redox Regulatory Changes of Circadian Rhythm by the Environmental Risk Factors Traffic Noise and Air Pollution.Antioxidants & redox signaling · 2022Review
- Time to learn: The role of the molecular circadian clock in learning and memory.Neurobiology of learning and memory · 2022Review
- Stress hormone signalling inhibits Th1 polarization in a CD4 T-cell-intrinsic manner via mTORC1 and the circadian gene PER1.Immunology · 2022Article
- The Circadian Molecular Machinery in CNS Cells: A Fine Tuner of Neuronal and Glial Activity With Space/Time Resolution.Frontiers in molecular neuroscience · 2022Review
- Time Restricted Feeding to the Light Cycle Dissociates Canonical Circadian Clocks and Physiological Rhythms in Heart Rate.Frontiers in pharmacology · 2022Review
- Heart neurons use clock genes to control myocyte proliferation.Science advances · 2021Article
32 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A main oscillator in the suprachiasmatic nucleus (SCN) conveys circadian information to the peripheral clock systems for the regulation of fundamental physiological functions. Although polysynaptic autonomic neural pathways between the SCN and the liver were observed in rats, whether activation of the sympathetic nervous system entrains clock gene expression in the liver has yet to be understood. To assess sympathetic innervation from the SCN to liver tissue, we investigated whether injection of adrenaline/noradrenaline (epinephrine/norepinephrine) or sympathetic nerve stimulation could induce mPer gene expression in mouse liver. Acute administration of adrenaline or noradrenaline increased mPer1 but not mPer2 expression in the liver of mice in vivo and in hepatic slices in vitro. Electrical stimulation of the sympathetic nerves or adrenaline injection caused an elevation of bioluminescence in the liver area of transgenic mice carrying mPer1 promoter-luciferase. Under a light-dark cycle, destruction of the SCN flattened the daily rhythms of not only mPer1, mPer2, and mBmal1 genes but also noradrenaline content in the liver. Daily injection of adrenaline, administered at a fixed time for 6 days, recovered oscillations of mPer2 and mBmal1 gene expression in the liver of mice with SCN lesion on day 7. Sympathetic nerve denervation by 6-hydroxydopamine flattened the daily rhythm of mPer1 and mPer2 gene expression. Thus, on the basis of the present results, activation of the sympathetic nerves through noradrenaline and/or adrenaline release was a factor controlling the peripheral clock.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.