ArticleThe Journal of physiology2003
Interaction between sympathetic nerve activation and muscle fibre contraction in resistance vessels of hamster retractor muscle.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Heterogeneous oxygenation in nonexercising triceps surae muscle during contralateral isometric exercise.European journal of applied physiology · 2006Trial
- Impaired modulation of sympathetic alpha-adrenergic vasoconstriction in contracting forearm muscle of ageing men.The Journal of physiology · 2005Trial
- Inhibition of alpha-adrenergic vasoconstriction in exercising human thigh muscles.The Journal of physiology · 2004Trial
- Blunted sympathetic vasoconstriction in contracting skeletal muscle of healthy humans: is nitric oxide obligatory?The Journal of physiology · 2003Trial
- The acute and chronic effects of local aerobic exercise on cardiovascular physiology.Experimental physiology · 2026Review
- Endogenous muscarinic acetylcholine receptor signaling blunts αAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Load carriage physiology in normoxia and hypoxia.European journal of applied physiology · 2024Article
- A Biophysical Model for Cardiovascular Effects of Acupuncture-Underlying Mechanisms Based on First Principles.Medical acupuncture · 2022Review
- Passive leg movement-induced vasodilation and exercise-induced sympathetic vasoconstriction.Autonomic neuroscience : basic & clinical · 2022Article
- Does sympathetic vasoconstriction contribute to metabolism: Perfusion matching in exercising skeletal muscle?Frontiers in physiology · 2022Review
- Effects of impaired microvascular flow regulation on metabolism-perfusion matching and organ function.Microcirculation (New York, N.Y. : 1994) · 2021Review
- Global Reach 2018 Heightened α-Adrenergic Signaling Impairs Endothelial Function During Chronic Exposure to Hypobaric Hypoxia.Circulation research · 2020Article
- AlphaPhysiological reports · 2018Article
- Skeletal muscle contraction-induced vasodilation in the microcirculation.Journal of exercise rehabilitation · 2017Review
- TRPVExperimental physiology · 2017Article
- Sympatholytic effect of intravascular ATP is independent of nitric oxide, prostaglandins, NaThe Journal of physiology · 2017Article
- Endothelium-dependent vasodilatory signalling modulates αThe Journal of physiology · 2016Article
- Differential α-adrenergic modulation of rapid onset vasodilatation along resistance networks of skeletal muscle in old versus young mice.The Journal of physiology · 2016Article
- Cardiovascular control during whole body exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
- Contracting human skeletal muscle maintains the ability to blunt α1 -adrenergic vasoconstriction during KIR channel and Na(+) /K(+) -ATPase inhibition.The Journal of physiology · 2015Article
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Abstract
The interaction between skeletal muscle contraction and sympathetic nerve activation (SNA) on blood flow during exercise has remained ambiguous due to indirect estimates of vasomotor control. In the hamster retractor muscle (n=54), interactions between three levels of SNA (approximately 3, 6 and 12 Hz) and of contractile activity (2.5, 10 and 20 % duty cycle) were studied in feed arteries (FA) and first- (1A), second- (2A), and third-order (3A) arterioles using intravital microscopy. During functional dilatation with rhythmic muscle contractions, sympathetic vasoconstriction was sustained in FA and 1A but impaired in 2A and 3A (P<0.05), where vessels 'escaped' from responding to SNA. To account for changes in baseline diameter and blood flow during contractions, vasodilatation was induced passively (2-3 levels) in resting muscles with papaverine or sodium nitroprusside. Compared to functional dilatation, the range of passive dilatation was similar in 3A and progressively greater in 2A, 1A and FA. With passive dilatation, SNA responses were sustained in 2A and increased with baseline diameter in 3A. Blood flow through FA (rest, approximately 20 nl s(-1)) increased approximately 5-fold during contractile activity and approximately 10-fold during passive dilatation. Absolute flow reductions (nl s(-1)) with SNA increased during contractile activity and during passive dilatation; relative flow reductions were impaired during functional dilatation (P<0.05) and remained constant during passive dilatation. Thus, SNA can restrict blood flow to exercising muscle by constricting FA and 1A while dilatation prevails in 2A and 3A. Such concerted interaction will promote oxygen extraction when blood flow is restricted to maintain arterial pressure.
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