Evidence map›Paper›PMID 12754249›Full record

ArticleJournal of bacteriology2003

The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).

Gerald L Newton, Teresa Koledin, Batia Gorovitz, Mamta Rawat, Robert C Fahey, Yossef Av-Gay

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Redox and Thiols in Archaea.Antioxidants (Basel, Switzerland) · 2020
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Ergothioneine is a secreted antioxidant in Mycobacterium smegmatis.Antimicrobial agents and chemotherapy · 2013
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Gerald L NewtonDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA.
Teresa Koledin
Batia Gorovitz
Mamta Rawat
Robert C Fahey
Yossef Av-Gay
University of British Columbia · CAUniversity of California San Diego · US

Funding

MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETSR01AI049174 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FAHEY, ROBERT C · 2000 to 2006
$1.7M
MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETSR21AI049174 · NIAID · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI FAHEY, ROBERT C · 2003 to 2003
$329k
FIC NIH HHS TW00976NIAID NIH HHS AI49174NIAID NIH HHS R01 AI049174NIAID NIH HHS R21 AI049174
6 · The paper itself

Abstract

Mycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharide 1D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins). A transposon mutant of Mycobacterium smegmatis shown to be GlcNAc-Ins and mycothiol deficient was sequenced to identify a putative glycosyltransferase gene designated mshA. The ortholog in Mycobacterium tuberculosis, Rv0486, was used to complement the mutant phenotype.

Indexed as

Amino Acid SequenceBacterial ProteinsCysteineDisaccharidesDNA Transposable ElementsGlycopeptidesGlycosyltransferasesInositolMolecular Sequence DataMutationMycobacterium smegmatisMycobacterium tuberculosisPyrazolesSequence AlignmentSulfhydryl CompoundsBacterial ProteinsCysteineDisaccharidesDNA Transposable ElementsGlycopeptidesGlycosyltransferasesInositolmycothiolPyrazolesSulfhydryl Compounds

Identifiers

PMID12754249
PMCPMC155378
OpenAlexW1990953428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.