ReviewJournal of mammary gland biology and neoplasia2002
Multispecies comparison of the casein gene loci and evolution of casein gene family.
Review in Journal of mammary gland biology and neoplasia, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 161 citations in OpenAlex.
- TheAnimals : an open access journal from MDPI · 2026Article
- Review
- Identification and Validation of Genus/Species-Specific Short InDels in Dairy Ruminants.BMC veterinary research · 2025Article
- Molecular Diversity of the Casein Gene Cluster in Bovidae: Insights from SNP Microarray Analysis.Animals : an open access journal from MDPI · 2024Article
- A Comprehensive Analysis ofAnimals : an open access journal from MDPI · 2024Article
- Anti-cancer potential of casein and its derivatives: novel strategies for cancer treatment.Medical oncology (Northwood, London, England) · 2024Review
- Variations in Casein Genes Are Associated with Milk Protein and Fat Contents in Sarda Goats (Animals : an open access journal from MDPI · 2023Article
- Sequencing and Characterization of αs2-Casein Gene (Animals : an open access journal from MDPI · 2023Article
- Identification and molecular evolution of the GLX genes in 21 plant species: a focus on the Gossypium hirsutum.BMC genomics · 2023Article
- Caseins: Versatility of Their Micellar Organization in Relation to the Functional and Nutritional Properties of Milk.Molecules (Basel, Switzerland) · 2023Review
- Article
- Identification and annotation of milk associated genes from milk somatic cells using expression and RNA-seq data.Bioinformation · 2022Article
- Article
- The molecular basis of mammary gland development and epithelial differentiation.Seminars in cell & developmental biology · 2021Review
- Comparative Genomics, Evolutionary and Gene Regulatory Regions Analysis of Casein Gene Family inFrontiers in genetics · 2021Article
- An improved LC-MS method to profile molecular diversity and quantify the six main bovine milk proteins, including genetic and splicing variants as well as post-translationally modified isoforms.Food chemistry: X · 2020Article
- Frequencies Evaluation of β-Casein Gene Polymorphisms in Dairy Cows Reared in Central Italy.Animals : an open access journal from MDPI · 2020Article
- Implications of kappa-casein evolutionary diversity for the self-assembly and aggregation of casein micelles.Royal Society open science · 2019Article
- Alternative splicing events expand molecular diversity of camel CSN1S2 increasing its ability to generate potentially bioactive peptides.Scientific reports · 2019Article
- Casein Gene Cluster in Camelids: Comparative Genome Analysis and New Findings on Haplotype Variability and Physical Mapping.Frontiers in genetics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caseins, the major milk proteins, are present in a genomic cluster spanning 250-350 kb. The divergence at the coding level between human, rodent, and cattle sequences is rather extensive for most of the genes in this region. Nevertheless, comparative analysis of genomic sequences harboring the casein gene cluster region of these species (with equal evolutionary distances 79-88 Myr) shows that the organization and orientation of the genes is highly conserved. The conserved gene structure indicates that the molecular diversity of the casein genes is achieved through variable use of exons in different species and high evolutionary divergence. Comparative analysis also revealed the presence within two species of uncharacterized casein family members and ruled out the previously held notion that another gene family, located in this region, is primate-specific. Several other new genes as well as conserved noncoding sequences with potential regulatory functions were identified. All genes identified in this region are, or are predicted to be, secreted proteins involved in mineral homeostasis, nutrition, and/or host defense, and are mostly expressed in the mammary and/or salivary glands. These observations suggest a possible common ancestry for the genes in this region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.