ReviewJournal of mammary gland biology and neoplasia2002
The evolutionary origins of maternal calcium and bone metabolism during lactation.
Review in Journal of mammary gland biology and neoplasia, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 78 citations in OpenAlex.
- Wild bonobos experience unusually low bone resorption during early lactation relative to humans and other mammals.Evolutionary human sciences · 2025Article
- Revealing genes related teat number traits via genetic variation in Yorkshire pigs based on whole-genome sequencing.BMC genomics · 2024Article
- Article
- Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner.bioRxiv : the preprint server for biology · 2024Article
- Article
- Crosstalk within a brain-breast-bone axis regulates mineral and skeletal metabolism during lactation.Frontiers in physiology · 2023Review
- Independent Skeletal Actions of Pituitary Hormones.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Pregnancy and lactation, a challenge for the skeleton.Endocrine connections · 2020Review
- Evolutionary Perspective in Rickets and Vitamin D.Frontiers in endocrinology · 2019Review
- Regulation of Skeletal Homeostasis.Endocrine reviews · 2018Review
- Actions of pituitary hormones beyond traditional targets.The Journal of endocrinology · 2018Review
- Alterations to maternal cortical and trabecular bone in multiparous middle-aged mice.Journal of musculoskeletal & neuronal interactions · 2017Article
- Functions of vasopressin and oxytocin in bone mass regulation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism.Endocrinology · 2015Article
- Article
- Article
- Osteocytic osteolysis: time for a second look?BoneKEy reports · 2012Review
- Sauropod dinosaur osteoderms from the Late Cretaceous of Madagascar.Nature communications · 2011Article
- Skeletal recovery after weaning does not require PTHrP.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Is tissue maturation necessary for flight? Changes in body composition during postnatal development in the big brown bat.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Calcium is required for skeletal growth in all vertebrate offspring. In eutherian mammals, calcium is provided by the mother via the placenta during fetal growth and via milk until weaning. Transferring calcium to offspring during pregnancy and lactation significantly stresses maternal calcium homeostasis. During human pregnancy, the extra calcium requirements are met primarily by an increase in absorption of calcium from the diet and by a modest increase in rates of bone resorption. In nursing mothers, the calcium required for milk production is generated by a dramatic increase in rates of bone resorption and a decrease in the rate of renal calcium excretion. To consider the evolution of these maternal adaptations in bone and calcium metabolism, comparisons are made across different species of mammals, and the fundamental problem of maternal transfer of calcium to young is explored in lower vertebrates. These comparisons suggest that maternal adaptations in calcium and bone metabolism during pregnancy and lactation in mammals originate from adaptations in bone and mineral metabolism that supply calcium for egg production in lower vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.