ArticleJournal of human genetics2003
Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm.
Article in Journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 43 citations in OpenAlex.
- Large language models assisted multi-effect variants mining on cerebral cavernous malformation familial whole genome sequencing.Computational and structural biotechnology journal · 2024Article
- Genomic variations associated with risk and protection against vincristine-induced peripheral neuropathy in pediatric cancer patients.NPJ genomic medicine · 2024Article
- Polymorphisms in Lysyl Oxidase Family Genes Are Associated With Intracranial Aneurysm Susceptibility in a Chinese Population.Frontiers in endocrinology · 2021Article
- Four differentially methylated gene pairs to predict the prognosis for early stage hepatocellular carcinoma patients.Journal of cellular physiology · 2018Article
- A Novel Association between Lysyl Oxidase Gene Polymorphism and Intracranial Aneurysm in Koreans.Yonsei medical journal · 2017Article
- Lack of association of lysyl oxidase (LOX) gene polymorphisms with intracranial aneurysm in a south Indian population.Molecular biology reports · 2013Article
- The genetics of vascular complications in autosomal dominant polycystic kidney disease (ADPKD).Current hypertension reviews · 2013Review
- Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5.BMC genetics · 2012Article
- The development and the use of experimental animal models to study the underlying mechanisms of CA formation.Journal of biomedicine & biotechnology · 2011Review
- Novel method of cell-free in vitro synthesis of the human fibroblast growth factor 1 gene.Journal of biomedicine & biotechnology · 2010Article
- Intracranial and abdominal aortic aneurysms: similarities, differences, and need for a new class of computational models.Annual review of biomedical engineering · 2008Review
- Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms.Human genetics · 2007Article
- The genetics of intracranial aneurysms.Journal of human genetics · 2006Review
- The Familial Intracranial Aneurysm (FIA) study protocol.BMC medical genetics · 2005Article
- Mapping a Mendelian form of intracranial aneurysm to 1p34.3-p36.13.American journal of human genetics · 2005Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously performed a genome-wide linkage study of intracranial aneurysm (IA) and found positive evidence of linkage at chromosomes 5q22-31, 7q11, and 14q22. In the present study, we focus on 5q31, where three candidate genes, fibroblast growth factor 1 (FGF1), fibrillin 2 (FBN2), and lysyl oxidase gene ( LOX) lie, and evaluate associations with IA. Genomic DNAs were obtained from 172 IA patients and 192 controls. Association analysis was performed with ten, five, and four single-nucleotide polymorphisms (SNPs) identified in FGF1, FBN2, and LOX, respectively. A difference in allelic frequency was observed for only the SNP at intron 4 in FGF1 (chi(2)=4.44, df=1, P=0.035). Although a haplotype association was observed with the combination of ten SNPs in FGF1 (chi(2)=16.04, df=1, P=0.00006), significant haplotype associations were not observed when haplotypes were constructed with the three, two, and four SNPs in FGF1 according to the linkage disequilibrium structure. No associations of FBN2 and LOX with IA were detected in the present study.
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