ArticleProceedings of the National Academy of Sciences of the United States of America2003
A new Drosophila spliceosomal intron position is common in plants.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Novel Introner-Like Elements in fungi Are Involved in Parallel Gains of Spliceosomal Introns.PloS one · 2015Article
- Recurrent loss of specific introns during angiosperm evolution.PLoS genetics · 2014Article
- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
- Widespread recurrent evolution of genomic features.Genome biology and evolution · 2012Review
- Evolution of spliceosomal introns following endosymbiotic gene transfer.BMC evolutionary biology · 2010Article
- Extensive, recent intron gains in Daphnia populations.Science (New York, N.Y.) · 2009Article
- Plant spliceosomal introns: not only cut and paste.Current genomics · 2008Article
- Alternative splicing: a missing piece in the puzzle of intron gain.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The nuclear OXPHOS genes in insecta: a common evolutionary origin, a common cis-regulatory motif, a common destiny for gene duplicates.BMC evolutionary biology · 2007Article
- Tempo and mode of spliceosomal intron evolution in actin of foraminifera.Journal of molecular evolution · 2006Article
- Analysis of ribosomal protein gene structures: implications for intron evolution.PLoS genetics · 2006Article
- Rates of intron loss and gain: implications for early eukaryotic evolution.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The pattern of intron loss.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Conservation versus parallel gains in intron evolution.Nucleic acids research · 2005Article
- Caenorhabditis phylogeny predicts convergence of hermaphroditism and extensive intron loss.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Prevalence of intron gain over intron loss in the evolution of paralogous gene families.Nucleic acids research · 2004Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The 25-year-old debate about the origin of introns between proponents of "introns early" and "introns late" has yielded significant advances, yet important questions remain to be ascertained. One question concerns the density of introns in the last common ancestor of the three multicellular kingdoms. Approaches to this issue thus far have relied on counts of the numbers of identical intron positions across present-day taxa on the assumption that the introns at those sites are orthologous. However, dismissing parallel intron gain for those sites may be unwarranted, because various factors can potentially constrain the site of intron insertion. Demonstrating parallel intron gain is severely handicapped, because intron sequences often evolve exceedingly fast and intron phylogenetic distributions are usually ambiguous, such that alternative loss and gain scenarios cannot be clearly distinguished. We have identified an intron position that was gained independently in animals and plants in the xanthine dehydrogenase gene. The extremely disjointed phylogenetic distribution of the intron argues strongly for separate gain rather than recurrent loss. If the observed phylogenetic pattern had resulted from recurrent loss, all observational support previously gathered for the introns-late theory of intron origins based on the phylogenetic distribution of introns would be invalidated.
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