ArticleThe Journal of clinical investigation2003
HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI-dependent manner.
Article in The Journal of clinical investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 152 citations in OpenAlex.
- Endothelial-protective effects of a G-protein-biased sphingosine-1 phosphate receptor-1 agonist, SAR247799, in type-2 diabetes rats and a randomized placebo-controlled patient trial.British journal of clinical pharmacology · 2021Trial
- Iberian Cured-Ham Consumption Improves Endothelial Function in Healthy Subjects.The journal of nutrition, health & aging · 2017Trial
- Development and validation of a predictive model for intraoperative hypothermia in patients undergoing video-assisted thoracoscopic surgery: a retrospective study.BMC anesthesiology · 2026Article
- Mechanisms of high-density lipoprotein in regulating blood-brain barrier function: insights and implications.Fluids and barriers of the CNS · 2025Review
- The Role of Scavenger Receptor BI in Sepsis.International journal of molecular sciences · 2024Review
- High-Density Lipoprotein-Associated Paraoxonase-1 (PON-1) and Scavenger Receptor Class B Type 1 (SRB-1) in Coronary Artery Disease: Correlation with Disease Severity.Journal of clinical medicine · 2024Article
- High-Density Lipoprotein Metabolism and Function in Cardiovascular Diseases: What about Aging and Diet Effects?Nutrients · 2024Review
- Endothelial Function in Dyslipidemia: Roles of LDL-Cholesterol, HDL-Cholesterol and Triglycerides.Cells · 2023Review
- Estradiol and HDL Function in Women - A Partnership for Life.The Journal of clinical endocrinology and metabolism · 2022Article
- Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation.Frontiers in cardiovascular medicine · 2022Review
- HDL and Endothelial Function.Advances in experimental medicine and biology · 2022Article
- High-Density Lipoprotein Therapy in Stroke: Evaluation of Endothelial SR-BI-Dependent Neuroprotective Effects.International journal of molecular sciences · 2020Article
- Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study.BMJ open · 2020Article
- SR-BI (Scavenger Receptor Class B Type 1) Is Critical in Maintaining Normal T-Cell Development and Enhancing Thymic Regeneration.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Targeting inflammation in metabolic syndrome.Translational research : the journal of laboratory and clinical medicine · 2016Review
- Article
- Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis.Advances in experimental medicine and biology · 2015Article
- HDL in sepsis - risk factor and therapeutic approach.Frontiers in pharmacology · 2015Review
- Cigarette smoking is associated with dose-dependent adverse effects on paraoxonase activity and fibrinogen in young women.Inhalation toxicology · 2014Article
- 17β-Estradiol regulates scavenger receptor class BI gene expression via protein kinase C in vascular endothelial cells.Endocrine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Cardiovascular diseases remain the leading cause of death in the United States. Two factors associated with a decreased risk of developing cardiovascular disease are elevated HDL levels and sex - specifically, a decreased risk is found in premenopausal women. HDL and estrogen stimulate eNOS and the production of nitric oxide, which has numerous protective effects in the vascular system including vasodilation, antiadhesion, and anti-inflammatory effects. We tested the hypothesis that HDL binds to its receptor, scavenger receptor class B type I (SR-BI), and delivers estrogen to eNOS, thereby stimulating the enzyme. HDL isolated from women stimulated eNOS, whereas HDL isolated from men had minimal activity. Studies with ovariectomized and ovariectomized/estrogen replacement mouse models demonstrated that HDL-associated estradiol stimulation of eNOS is SR-BI dependent. Furthermore, female HDL, but not male HDL, promoted the relaxation of muscle strips isolated from C57BL/6 mice but not SR-BI null mice. Finally, HDL isolated from premenopausal women or postmenopausal women receiving estradiol replacement therapy stimulated eNOS, whereas HDL isolated from postmenopausal women did not stimulate eNOS. We conclude that HDL-associated estrodial is capable of the stimulating eNOS. These studies establish a new paradigm for examining the cardiovascular effects of HDL and estrogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.