ArticleThe Biochemical journal2003
Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP).
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease.The Journal of cell biology · 2025Article
- Review
- Activation of endo-lysosomal two-pore channels by NAADP and PI(3,5)PCell calcium · 2022Review
- The lysosomotrope GPN mobilises CaJournal of cell science · 2021Article
- Conceptual Evolution of Cell Signaling.International journal of molecular sciences · 2019Review
- Activity-Dependent Exocytosis of Lysosomes Regulates the Structural Plasticity of Dendritic Spines.Neuron · 2017Article
- Preferential Coupling of the NAADP Pathway to Exocytosis in T-Cells.Messenger (Los Angeles, Calif. : Print) · 2015Article
- NAADP/TPC2/Ca(2+) Signaling Inhibits Autophagy.Communicative & integrative biology · 2013Article
- Mechanisms of G protein-coupled estrogen receptor-mediated spinal nociception.The journal of pain · 2012Article
- Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channels.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP.FEBS letters · 2010Review
- Deviant nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated Ca2+ signaling upon lysosome proliferation.The Journal of biological chemistry · 2010Article
- Calcium signaling via two-pore channels: local or global, that is the question.American journal of physiology. Cell physiology · 2010Review
- The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.Pflugers Archiv : European journal of physiology · 2009Review
- Excitatory effects of human immunodeficiency virus 1 Tat on cultured rat cerebral cortical neurons.Neuroscience · 2008Article
- Time sensing by NAADP receptors.The Biochemical journal · 2006Article
- The priming effect of extracellular UTP on human neutrophils: Role of calcium released from thapsigargin-sensitive intracellular stores.Purinergic signalling · 2005Article
- Spontaneous opening of T-type Ca2+ channels contributes to the irregular firing of dopamine neurons in neonatal rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- NAD - new roles in signalling and gene regulation in plants.The New phytologist · 2004Review
- Determination of cellular nicotinic acid-adenine dinucleotide phosphate (NAADP) levels.The Biochemical journal · 2004Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
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Abstract
Nicotinic acid-adenine dinucleotide phosphate (NAADP) is a recently described potent intracellular Ca(2+)-mobilizing messenger active in a wide range of diverse cell types. In the present study, we have investigated the interaction of NAADP with other Ca(2+)-mobilizing messengers in the release of transmitter at the frog neuromuscular junction. We show, for the first time, that NAADP enhances neurosecretion in response to inositol 1,4,5-trisphosphate (IP(3)), cADP-ribose (cADPR) and sphingosine 1-phosphate (S1P), but not sphingosylphosphorylcholine. Thapsigargin was without effect on transmitter release in response to NAADP, but blocked the responses to subsequent application of IP(3), cADPR and S1P and their potentiation by NAADP. Asynchronous neurotransmitter release may therefore involve functional coupling of endoplasmic reticulum Ca(2+) stores with distinct Ca(2+) stores targeted by NAADP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.