ArticleProceedings of the National Academy of Sciences of the United States of America2003
Dictyostelium and Acanthamoeba myosin II assembly domains go to the cleavage furrow of Dictyostelium myosin II-null cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Biphasic targeting and cleavage furrow ingression directed by the tail of a myosin II.The Journal of cell biology · 2010Article
- 14-3-3, an integrator of cell mechanics and cytokinesis.Small GTPases · 2010Article
- Expression of Y53A-actin in Dictyostelium disrupts the cytoskeleton and inhibits intracellular and intercellular chemotactic signaling.The Journal of biological chemistry · 2010Article
- Mechanosensing through cooperative interactions between myosin II and the actin crosslinker cortexillin I.Current biology : CB · 2009Article
- Physical model of contractile ring initiation in dividing cells.Biophysical journal · 2008Article
- Temperature dependence of myosin-II tail fragment assembly.Journal of muscle research and cell motility · 2008Article
- S-adenosylhomocysteine hydrolase is localized at the front of chemotaxing cells, suggesting a role for transmethylation during migration.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Phosphorylation of actin Tyr-53 inhibits filament nucleation and elongation and destabilizes filaments.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Cytokinesis depends on the motor domains of myosin-II in fission yeast but not in budding yeast.Molecular biology of the cell · 2005Article
- Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Biological, biochemical, and kinetic effects of mutations of the cardiomyopathy loop of Dictyostelium myosin II: importance of ALA400.The Journal of biological chemistry · 2005Article
- Blebbistatin and blebbistatin-inactivated myosin II inhibit myosin II-independent processes in Dictyostelium.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Dictyostelium myosin bipolar thick filament formation: importance of charge and specific domains of the myosin rod.PLoS biology · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
How myosin II localizes to the cleavage furrow of dividing cells is largely unknown. We show here that a 283-residue protein, assembly domain (AD)1, corresponding to the AD in the tail of Dictyostelium myosin II assembles into bundles of long tubules when expressed in myosin II-null cells and localizes to the cleavage furrow of dividing cells. AD1 mutants that do not polymerize in vitro do not go to the cleavage furrow in vivo. An assembly-competent polypeptide corresponding to the C-terminal 256 residues of Acanthamoeba myosin II also goes to the cleavage furrow of Dictyostelium myosin II-null cells. When overexpressed in wild-type cells, AD1 colocalizes with endogenous myosin II (possibly as a copolymer) in interphase, motile, and dividing cells and under caps of Con A receptors but has no effect on myosin II-dependent functions. These results suggest that neither a specific sequence, other than that required for polymerization, nor interaction with other proteins is required for localization of myosin II to the cleavage furrow.
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